PMID: 2502300Jul 17, 1989Paper

Carbonic anhydrase activity in the peripheral nervous system of rat: the enzyme as a marker for muscle afferents

Brain Research
M J SzabolcsG E Schaden

Abstract

The distribution of carbonic anhydrase (CA) activity was determined histochemically using Hansson's cobalt phosphate method in cross-sections of peripheral nerves from rats. As the studied nerves contain either efferent, proprioceptive or exteroceptive myelinated fibres, our survey particularly focused on the question whether CA-reactive nerve fibres are functionally related. Intense CA activity was detected in all large diameter (8-12 microns) muscle afferents. The amount of similarly reactive cutaneous afferents was negligibly low (3.6%). Efferent fibres displayed only weak CA activity, which was confined to the small myelinated fibres (3-6 microns). Moderate staining could be assessed in medium-sized (4-11 microns) proprioceptive fibres. The same reactivity occurred in a sizeable percentage (11.4%) of exteroceptive afferents. Their diameters ranged from 4 to 11 microns. These results indicated, that high enzyme activity is found predominantly in large-calibre proprioceptive afferents, which according to Hunt's classification were identified as group IA and IB fibres. Further confirmation for our observations was obtained by demonstrating high levels of enzyme activity in primary nerve endings of muscle spindles (IA fibres) a...Continue Reading

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Citations

Feb 19, 1993·Brain Research. Developmental Brain Research·V MayeuxJ Valmier
Nov 1, 1996·Archives of Oral Biology·H IchikawaT Sugimoto
May 24, 2016·Expert Review of Neurotherapeutics·Claudiu T Supuran
May 1, 1993·The Journal of Hand Surgery·M DeutingerG Freilinger
Jan 1, 1993·Microsurgery·M DeutingerG Freilinger
Sep 27, 2019·International Journal of Molecular Sciences·Gustavo ProvensiSilvia Fossati
Jan 1, 1992·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·N F Capra, D Dessem
Jan 1, 1990·Biomedizinische Technik. Biomedical Engineering·H GruberI Gruber
Jan 1, 1994·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·K F Chung
Jan 22, 2000·The Journal of Hand Surgery·Y KawasakiS Park

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