PMID: 8964532Apr 1, 1996Paper

Carbonic anhydrase activity is increased in retinal pigmented epithelium and choriocapillaris of RCS rats

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
M EichhornE Lütjen-Drecoll

Abstract

In Royal College of Surgeons (RCS) rats the retinal pigmented epithelium (RPE) exhibits defective phagocytosis of rod outer segments, causing degeneration of the photoreceptor layer. It is not known whether another function of the RPE, ion and fluid transport, is also affected by the disease. One enzyme involved in modulation of RPE transport activities is carbonic anhydrase (CA). To clarify whether changes in CA activity are correlated with the process of retinal degeneration, the localization of CA activity in RCS rat eyes was investigated. Eyes of 12 RCS rats and 12 age-matched congenic controls of different ages were studied, using a modified histochemical method of Hansson for light and electron microscopy. Control eyes showed CA staining in corneal endothelium, both layers of ciliary epithelium, Müller cells, inner segments of photoreceptors, and RPE cells. In RPE the apical membranes were most intensely stained. In RCS rats, changes in CA staining were seen only in the posterior segment of rats 6 and 7 months of age. Most of the RPE cells were more intensely stained than those of age-matched controls, especially due to increased CA activity in the basolateral membrane infoldings. Adjacent endothelial cells of the chorioc...Continue Reading

References

Dec 1, 1976·Acta Physiologica Scandinavica·Y Ridderstråle
May 1, 1991·Experimental Eye Research·K YamaguchiJ E Turner
Jun 1, 1985·Acta Physiologica Scandinavica·E Lütjen-DrecollE H Bárány
Oct 1, 1989·Archives of Ophthalmology·G A FishmanL M Jampol
Sep 1, 1988·Archives of Ophthalmology·S N CoxA C Bird
Nov 1, 1986·Archives of Ophthalmology·M F Marmor, A Negi
Jan 1, 1967·Histochemie. Histochemistry. Histochimie·H P Hansson
Jan 1, 1983·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E Lütjen-DrecollM Eichhorn
Mar 1, 1983·Experimental Eye Research·R B Caldwell, B J McLaughlin
Oct 1, 1994·Experimental Eye Research·M SchreckenbergerE Lütjen-Drecoll

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Citations

Jan 8, 2013·Ophthalmology·Camiel J F BoonMary J van Schooneveld
Nov 9, 2011·Experimental Eye Research·Christian Albrecht May
Jul 23, 2021·Progress in Retinal and Eye Research·Raphael LejoyeuxJay Chhablani

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