PMID: 9179546May 1, 1997Paper

Carbonic anhydrase II in the cerebrospinal fluid: its value as a disease marker

European Journal of Clinical Investigation
A K ParkkilaH Rajaniemi

Abstract

Carbonic anhydrase (CA) II is the predominant CA isoenzyme in the brain of mammals. We have recently developed a dual-label time-resolved immunofluorometric assay to quantify minute amounts of CA I and II in the cerebrospinal fluid (CSF). The present study was aimed at elucidating the clinical value of such measurements in the case of neurological disorders. Lumbar CSF samples were obtained from 111 patients suffering from various neurological diseases and from 97 control patients with no specific signs of central nervous system diseases. The highest CA II concentrations were found in patients with brain infarction (median 66.5 micrograms L-1, n = 20), whereas the control patients had markedly lower values (median 7.8 micrograms L-1, n = 97). Relative to a reference range calculated from the control material (10.2 +/- 17.2 micrograms L-1), the sensitivity of CA II measurement in differentiating brain infarction was 100%. Patients with transient ischaemic attack (median 11.2 micrograms L-1, n = 9), multiple sclerosis (median 14.7 micrograms L-1, n = 18) or epilepsy (median 20.3 micrograms L-1, n = 17) usually had CA II concentrations within the normal range, but those with central nervous system infection (n = 14), dementia (n =...Continue Reading

Citations

Nov 16, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·P BrustB Johannsen
May 28, 2017·Pathophysiology : the Official Journal of the International Society for Pathophysiology·David E ConnorJ Steven Alexander
Apr 18, 2008·Advances in Health Sciences Education : Theory and Practice·Jules A KieserVicki Livingstone
Oct 7, 2011·Metallomics : Integrated Biometal Science·Renee N EasterJoseph A Caruso

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