PMID: 2500364Jun 5, 1989Paper

Carbonic anhydrase II is induced in HL-60 cells by 1,25-dihydroxyvitamin D3: a model for osteoclast gene regulation

FEBS Letters
L Hillstrom ShapiroR E Tashian

Abstract

Carbonic anhydrase II (CA II) generates the H+ required for osteoclast-mediated bone resorption in humans. We have developed the human promyelocytic cell line HL-60 as a model system with which to study the osteoclast-specific expression of the CA II gene. Treatment of the cell line with 1,25-dihydroxyvitamin D3 resulted in a dramatic de novo induction of CA II at both the protein and mRNA levels. CA II mRNA was also induced to a lesser extent by 12-O-tetradecanoyl phorbol 13-acetate. Treatment with dimethyl sulfoxide did not increase CA II mRNA. These findings indicate that the HL-60 cell line will be a useful model system to study the osteoclast-specific expression of the CA II gene.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jun 11, 1987·Nucleic Acids Research·J C MontgomeryD Hewett-Emmett
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S E LewisR E Tashian
Sep 1, 1985·Archives of Biochemistry and Biophysics·P EngbergS Lindskog
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein

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Citations

Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M H ZhengJ M Papadimitriou
Jun 22, 2000·Biochemical and Biophysical Research Communications·S NakaT Takeya
Jan 1, 2000·The American Journal of the Medical Sciences·R I HenkinR P Agarwal
Oct 1, 1993·Baillière's Clinical Rheumatology·B R MacDonald, M Gowen
Nov 23, 2011·Journal of Proteome Research·Gabriela Bomfim FerreiraChantal Mathieu

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