Carbonic anhydrase in the normal rat stomach and duodenum and after treatment with omeprazole and ranitidine

Acta Physiologica Scandinavica
G LönnerholmG Flemström

Abstract

A low pH in the lumen of the stomach and duodenum stimulates gastroduodenal mucosal secretion of bicarbonate, particularly in the duodenum. Long-term deprivation of this acid stimulus might affect the ability of the mucosa to secrete bicarbonate, with a consequent decrease in mucosal protection against the acid. This could occur by 'down-regulation' of carbonic anhydrase (CA) activity in the bicarbonate-transporting cells. Levels of CA activity and amounts of CA isoenzymes in rat gastric and duodenal mucosa were determined by biochemical assay and histochemical and immunohistochemical staining. Control animals and animals pre-treated for 4-6 weeks with the histamine H2-receptor antagonist ranitidine (600 mg kg-1 daily) or the H+,K+-ATPase inhibitor omeprazole (28 mg kg-1 daily) were examined. Both drugs are potent inhibitors of gastric secretion of acid. Both gastric and duodenal mucosal total CA activity and the distribution of isoenzymes were very similar in control animals and animals treated with these drugs. In the stomach, CA II was found in the surface epithelial and parietal cells. In the duodenum both CA I and CA II were observed. The staining for CA I was restricted to a small number of villus cells which looked like ...Continue Reading

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Citations

Jul 1, 1991·Digestive Diseases and Sciences·R A EricksonA S Tarnawski
Oct 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mari LeppilampiMarkus Sjöblom
Jul 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Markus SjöblomUrsula Seidler
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Aug 4, 2005·Upsala Journal of Medical Sciences·Markus Sjöblom
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Mar 25, 2006·The Journal of Physiology·Misa MizumoriYasutada Akiba
Apr 1, 2005·American Journal of Physiology. Cell Physiology·Jie XuManoocher Soleimani
Jun 10, 2005·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A F AhmedN A Misk
Apr 22, 2017·Oncotarget·Kiyong Na, Hyun-Soo Kim
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May 12, 1998·The American Journal of Physiology·L L Clarke, M C Harline

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