Carbonic anhydrase inhibition and cerebral cortical oxygenation in the rat

Advances in Experimental Medicine and Biology
J C LaManna, K A McCracken

Abstract

We report here the results of our study of the carbonic anhydrase inhibitor acetazolamide on cerebral vascular and metabolic function, correlated with the effects of this agent on systemic arterial blood gases and pH. We found that the effects of acetazolamide were to increase PaO2, decrease bicarbonate ion concentration and decrease pH. While these effects were maintained for many hours after both high and low dose acetazolamide, the cerebral metabolic and vascular effects of the drug were transient. The central effects of carbonic anhydrase inhibition were consistent with increased oxygen delivery and increased tissue oxygenation. Hypoxia such as encountered at altitude, represents a challenge to the mechanisms which control blood flow in the brain. The decreased arterial oxygen content at altitude is a ventilatory drive which has the effect of 1) increasing somewhat the PaO2; 2) decreasing the PaCO2; 3) alkalinizing the blood. The decreased PaCO2 then leads to decreased CBF compounding the problem of hypoxemia. In this situation, increasing CBF helps to relieve the tissue hypoxia. This has been done by either increased inhalation of CO2 (Harvey et al., 1988) or by acetazolamide (Cain and Dunn, 1966; Forwand et al., 1968). A ...Continue Reading

Citations

Jun 1, 2007·Antioxidants & Redox Signaling·Obinna Ndubuizu, Joseph C LaManna
Jan 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R B Buxton, L R Frank
Sep 1, 1996·Journal of Magnetic Resonance Imaging : JMRI·P HederaR P Friedland
Jan 6, 2012·The Journal of Physiology·Jui-Lin FanPhilip N Ainslie
Apr 16, 1993·Brain Research. Developmental Brain Research·L VelíŝekW Cammer

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