Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity

Expert Opinion on Emerging Drugs
Claudiu T Supuran

Abstract

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes in mammals, being involved in numerous biosynthetic processes, including gluconeogenesis, lipogenesis and ureagenesis. It has recently emerged that CA inhibitors (CAIs) targeting the mitochondrial isoforms CA VA and VB have potential as novel antiobesity drugs. This Editorial discusses the biochemical and biological rationale for the use of CAIs in the management of obesity.

References

Aug 15, 1995·The Biochemical Journal·C J LynchK F Lanoue
Mar 1, 1995·The International Journal of Biochemistry & Cell Biology·P V Attwood
Mar 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S A HazenC J Lynch
Dec 1, 1996·Progress in Lipid Research·J B Allred, K E Reilly
Dec 25, 2002·Medicinal Research Reviews·Claudiu T SupuranAngela Casini
Apr 10, 2003·JAMA : the Journal of the American Medical Association·Kishore M GaddeK Ranga R Krishnan
Feb 20, 2004·Journal of Medicinal Chemistry·Daniela VulloClaudiu T Supuran
Jan 3, 2008·Nature Reviews. Drug Discovery·Claudiu T Supuran
Jun 10, 2008·Expert Opinion on Emerging Drugs·Claudiu T SupuranGiuseppina De Simone
Jul 23, 2008·Bioorganic & Medicinal Chemistry Letters·Sally-Ann PoulsenClaudiu T Supuran
Oct 1, 2009·Clinical Cornerstone·Christopher P Cannon, Amit Kumar
Oct 31, 2009·Nature Reviews. Drug Discovery·Dan Jones
Mar 6, 2010·Gastroenterology Clinics of North America·Lee M Kaplan
Mar 29, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C K KramerJ L Gross
Jun 21, 2011·Epilepsy Research·Alberto VerrottiSalvatore Grosso
Sep 17, 2011·Nature Reviews. Drug Discovery·Dario Neri, Claudiu T Supuran
Oct 26, 2011·Reproduction in Domestic Animals = Zuchthygiene·A RizzoR L Sciorsci
Jan 18, 2012·Handbook of Experimental Pharmacology·J Antel, J Hebebrand

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Citations

Apr 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gul N ShahWilliam S Sly
Apr 24, 2013·Expert Opinion on Therapeutic Patents·Andrea ScozzafavaFabrizio Carta
Jul 15, 2015·Expert Review of Neurotherapeutics·Claudiu T Supuran
Mar 7, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Namrata SingasaneMrunmayee P Toraskar
Dec 2, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Claudiu T Supuran
Feb 16, 2013·Journal of Enzyme Inhibition and Medicinal Chemistry·Fortunato MigliardiniClemente Capasso
Mar 16, 2013·Journal of Enzyme Inhibition and Medicinal Chemistry·Aditi SharmaClaudiu T Supuran
Feb 12, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Murat BozdagClaudiu T Supuran
Jul 19, 2012·Journal of Enzyme Inhibition and Medicinal Chemistry·Anna-Kaisa HarjuSeppo Parkkila
Jun 30, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Ozen Ozensoy GulerClaudiu T Supuran
Feb 24, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·F Zehra KüçükbayClaudiu T Supuran
Feb 16, 2016·Expert Opinion on Drug Metabolism & Toxicology·Claudiu T Supuran
Jun 19, 2013·Bioorganic & Medicinal Chemistry·Muhammet TancClaudiu T Supuran
Apr 1, 2015·Future Medicinal Chemistry·Luca Costantino, Daniela Barlocco
May 24, 2016·Expert Review of Neurotherapeutics·Claudiu T Supuran
Jun 9, 2016·Journal of Agricultural and Food Chemistry·Giosuè CostaStefano Alcaro
Nov 2, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Erol LicsandruClaudiu T Supuran
Feb 13, 2014·Bioorganic & Medicinal Chemistry Letters·Aiga GrandaneClaudiu T Supuran
Jun 24, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Murat BozdagClaudiu T Supuran
Jul 29, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Morteza AbdoliClaudiu T Supuran
Dec 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ylenia CauMaurizio Botta
Dec 19, 2018·Chemical Communications : Chem Comm·Andrea AngeliClaudiu T Supuran
Mar 1, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Meng-Tsang HsiehDian-Jeng Li
Jun 18, 2019·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Yanshuang WangLiyun Zhao
Jul 14, 2016·The Biochemical Journal·Claudiu T Supuran
Feb 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela VulloClaudiu T Supuran
Mar 17, 2020·Expert Opinion on Drug Metabolism & Toxicology·Claudiu T Supuran
Jun 23, 2018·Current Medicinal Chemistry·Murat BozdagFabrizio Carta
Mar 25, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Marco BragagniClaudiu T Supuran
Nov 19, 2020·International Journal of Molecular Sciences·Cecilia Zavala-TecuapetlaHiram Luna-Munguia
May 22, 2020·ACS Medicinal Chemistry Letters·Francesca MancusoRosaria Gitto
Apr 25, 2020·Bioorganic & Medicinal Chemistry·Aiga GrandaneClaudiu T Supuran

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