Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions

Bioorganic & Medicinal Chemistry Letters
Anthony BertucciClaudiu T Supuran

Abstract

The inhibition of a coral carbonic anhydrase (CA, EC 4.2.1.1) has been investigated with a series of inorganic anions such as halogenides, pseudohalogenides, bicarbonate, carbonate, nitrate, nitrite, hydrogen sulfide, bisulfite, perchlorate, sulfate. The full-length scleractinian coral Stylophora pistillata CA, STPCA, has a significant catalytic activity for the physiological reaction of CO(2) hydration to bicarbonate, similarly to the ubiquitous human isoforms hCA I (cytosolic) and hCA VI (secreted). The best STPCA anion inhibitors were bromide, iodide, carbonate, and sulfamate, with inhibition constants of 9.0-10.0 microM.

References

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Dec 25, 2003·Journal of Enzyme Inhibition and Medicinal Chemistry·Daniela VulloClaudiu T Supuran
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Oct 27, 2004·Bioorganic & Medicinal Chemistry Letters·Alessio InnocentiClaudiu T Supuran
Jan 25, 2005·Bioorganic & Medicinal Chemistry Letters·Alessio InnocentiClaudiut Supuran
Mar 5, 2005·Bioorganic & Medicinal Chemistry Letters·Jean-Yves WinumClaudiu T Supuran
Mar 23, 2005·Bioorganic & Medicinal Chemistry Letters·Alessio InnocentiClaudiu T Supuran
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Apr 20, 2006·Bioorganic & Medicinal Chemistry Letters·Daniela VulloClaudiu T Supuran
Sep 26, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Hidekazu TohseHiromichi Nagasawa
Nov 28, 2006·Bioorganic & Medicinal Chemistry Letters·Isao NishimoriClaudiu T Supuran
Jan 30, 2007·Bioorganic & Medicinal Chemistry Letters·Alessio InnocentiClaudiu T Supuran
May 4, 2007·Bioorganic & Medicinal Chemistry·Claudiu T Supuran, Andrea Scozzafava
Jan 3, 2008·Nature Reviews. Drug Discovery·Claudiu T Supuran

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Citations

Feb 15, 2011·Marine Biotechnology·Anthony BertucciDidier Zoccola
Nov 4, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Furkan OrhanClaudiu T Supuran
Jun 9, 2016·Marine Drugs·Didier ZoccolaSylvie Tambutté
Jun 13, 2009·Bioorganic & Medicinal Chemistry·Anthony BertucciClaudiu T Supuran
Jul 26, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Rosa PerfettoClemente Capasso
Feb 24, 2010·Bioorganic & Medicinal Chemistry·Anthony BertucciClaudiu T Supuran

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