Carbonic anhydrase modification (chemical and biological) is an attractive strategy for its diverse application to accelerate the absorption of CO2 from a flue gas with improved activity and stability. This article reports various possibilities of CA modification using metal-ligand homologous chemistry, cross-linking agents, and residue- and group-specific and genetic modifications, and assesses their role in carbon management. Chemically modified carbonic anhydrase is able to improve the absorption of carbon dioxide from a gas stream into mediation compounds with enhanced sequestration and mineral formation. Genetically modified CA polypeptide can also increase carbon dioxide conversion. Chemical modification of CA can be categorized in terms of (i) residue-specific modification (involves protein-ligand interaction in terms of substitution/addition) and group-specific modifications (based on the functional groups of the target CA). For every sustainable change, there should be no/limited toxic or immunological response. In this review, several CA modification pathways and biocompatibility rules are proposed as a theoretical support for emerging research in this area.
Principles of enzyme stabilization. V. The possibility of enzyme selfstabilization under the action of potentially reversible intramolecular cross-linkages of different length
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Neovascularization effect of biodegradable gelatin microspheres incorporating basic fibroblast growth factor
Metal binding specificity in carbonic anhydrase is influenced by conserved hydrophobic core residues
A plant-type (beta-class) carbonic anhydrase in the thermophilic methanoarchaeon Methanobacterium thermoautotrophicum
Tissue and intracellular localization of indican and the purification and characterization of indican synthase from indigo plants
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Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II
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Chemical modification of lysine residues in Bacillus alpha-amylases: effect on activity and stability
Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II
A factorial analysis of silanization conditions for the immobilization of oligonucleotides on glass surfaces
Synthesis of peptides and proteins without cysteine residues by native chemical ligation combined with desulfurization
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Kinetic characterization of wild-type and proton transfer-impaired variants of beta-carbonic anhydrase from Arabidopsis thaliana
Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling
A comparative study of the catalytic mechanisms of the zinc and cadmium containing carbonic anhydrase
Methylation of the guanidino group of arginine residues prevents citrullination by peptidylarginine deiminase IV
Why are proteins charged? Networks of charge-charge interactions in proteins measured by charge ladders and capillary electrophoresis
Chemical modification results in hyperactivation and thermostabilization of Fusarium solani glucoamylase
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
Designing adsorbents for CO2 capture from flue gas-hyperbranched aminosilicas capable of capturing CO2 reversibly
Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding
Facile conversion of cysteine and alkyl cysteines to dehydroalanine on protein surfaces: versatile and switchable access to functionalized proteins
Lysine acetylation can generate highly charged enzymes with increased resistance toward irreversible inactivation
Observation of a calcium-binding site in the gamma-class carbonic anhydrase from Pyrococcus horikoshii
Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity
Characterization of a Mesorhizobium loti alpha-type carbonic anhydrase and its role in symbiotic nitrogen fixation
Electron-deficient alkynes as cleavable reagents for the modification of cysteine-containing peptides in aqueous medium
The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins
Regulation of expression and biochemical characterization of a beta-class carbonic anhydrase from the plant growth-promoting rhizobacterium, Azospirillum brasilense Sp7
Carbon dioxide postcombustion capture: a novel screening study of the carbon dioxide absorption performance of 76 amines
Carbonic anhydrase activity in Mytilus galloprovincialis digestive gland: sensitivity to heavy metal exposure
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium
Immobilization of carbonic anhydrase enzyme purified from Bacillus subtilis VSG-4 and its application as CO(2) sequesterer
DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae
Influence of protein interactions on oxidation/reduction midpoint potentials of cofactors in natural and de novo metalloproteins
Carbonic anhydrase immobilized on hollow fiber membranes using glutaraldehyde activated chitosan for artificial lung applications
Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases
Directed evolution of an ultrastable carbonic anhydrase for highly efficient carbon capture from flue gas
Cloning and expression of gamma carbonic anhydrase from Serratia sp. ISTD04 for sequestration of carbon dioxide and formation of calcite
The zinc coordination pattern in the η-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families
Investigating the adduct formation of organic mercury species with carbonic anhydrase and hemoglobin from human red blood cell hemolysate by means of LC/ESI-TOF-MS and LC/ICP-MS
Cloning, expression and biochemical characterization of a β-carbonic anhydrase from the soil bacterium Enterobacter sp. B13
Enhanced In Vitro Biocompatibility of Chemically Modified Poly(dimethylsiloxane) Surfaces for Stable Adhesion and Long-term Investigation of Brain Cerebral Cortex Cells
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