Carboplatin and paclitaxel in metastatic or recurrent cervical cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Dimitrios PectasidesTheofanis Economopoulos

Abstract

The purpose of this study was to evaluate the activity and toxicity of carboplatin and paclitaxel combination in advanced or recurrent carcinoma of the cervix. Fifty-one eligible patients with measurable advanced or recurrent cervical carcinoma were treated with carboplatin (area under the curve, 5) and paclitaxel 175 mg/m every 3 weeks for 6 to 9 cycles or until disease progression or unacceptable toxicity. Eight complete (16%) and 19 partial responses (37%) occurred, for an overall response rate (RR) of 53% (95% confidence interval [CI], 39%-67%). The median progression-free survival was 6 months (95% CI, 5.4-6.5 months), and the median overall survival was 13 months (95% CI, 11.4-14.5 months). The RR was higher in patients with disease outside a previously irradiated site compared with those with disease in a previously irradiated field (68% vs 30%) (P = 0.011). Patients previously treated with chemoradiation had an RR of 28%, whereas in those previously treated with radiotherapy alone, the RR was 68% (P = 0.023). There was no statistically significant difference between histology and response to therapy. Patients with performance status of 0 or 1 had a higher RR than those with worse performance status. Toxicity was general...Continue Reading

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Citations

Aug 5, 2015·Journal of Clinical Medicine·Hun Soon JungYoung Kee Shin
Jun 4, 2015·International Journal of Molecular Sciences·Hun Soon JungYoung Kee Shin
Feb 26, 2016·Annals of Medicine·Smitha V BavaRuby John Anto
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Mar 4, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ryo KitagawaHiroyuki Yoshikawa
Aug 2, 2017·American Journal of Clinical Oncology·Hiroko MachidaKoji Matsuo
Feb 22, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Takeshi HisamatsuTadashi Kimura
Nov 1, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Maki MatodaNobuhiro Takeshima
Jul 6, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Perry W GrigsbyGiuseppe Del Priore
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Dec 17, 2011·Archives of Gynecology and Obstetrics·Jong Ha HwangJoo-Young Kim

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