PMID: 9445194Jan 28, 1998Paper

Carboplatin and teniposide concurrent with radiotherapy in patients with glioblastoma multiforme: a phase II study

Cancer
A A BrandesM V Florentino

Abstract

The outcome after treatment for glioblastoma remains poor. Therefore, the authors evaluated the long term efficacy and toxicity of treatment with radiotherapy and concurrent carboplatin plus teniposide followed by three cycles of carmustine in patients who underwent resection for glioblastoma. Fifty-six newly diagnosed patients with glioblastoma underwent radiotherapy (1.8-2 gray [Gy]/day, 5 days a week using limited fields up to 60 Gy), and concurrent chemotherapy with carboplatin (350 mg/m2) on Days 1, 22, and 43, and teniposide (50 mg/m2) on Days 1, 2, 3, 22, 23, 24, 43, 44, and 45. Four weeks after the end of radiotherapy, patients were given carmustine (200 mg/m2) every 8 weeks for 3 cycles. Treatment then was suspended, but if disease progression was found, treatment was resumed using different drugs. All 56 patients were evaluated for time to progression (TTP) and median survival time (MST). The TTP was 7.5 months and the MST was 12.5 months. Toxicity manifested as thrombocytopenia and in most cases was acceptable. Four patients (7.1%) had radiation necrosis at 2, 2, 7, and 9 months, respectively, from the end of radiotherapy. The results obtained in the current study with concurrent radiochemotherapy in patients with gl...Continue Reading

References

Jul 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B JeremicL Mijatovic
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
May 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W K YungM J Gleason
May 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E E Vokes, R R Weichselbaum
Jul 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D R MacdonaldJ G Cairncross
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·K E WallnerM G Malkin
Jan 1, 1989·Seminars in Surgical Oncology·T J Dougherty
Jun 1, 1989·Neurology·L M DeAngelisJ B Posner
Jan 1, 1988·Journal of Neuro-oncology·R W WalkerJ B Posner
Apr 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·O F LangeW Scheef
Sep 1, 1980·International Journal of Radiation Oncology, Biology, Physics·G E ShelineV Smith
Jul 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R P DinapoliJ A Maier
Jan 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S C ScholdD D Bigner
Feb 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J GlantzM J Egorin

❮ Previous
Next ❯

Citations

Mar 30, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Tong SunZeng-Ming Yang
Nov 19, 2013·Pharmaceutical Patent Analyst·Jessica K NorbergEmmanuelle J Meuillet
Jan 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M BredelJ A Hainfellner
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y CaoS M Prescott
Feb 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Siva Kumar KolluriXiao-kun Zhang
Jul 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi NishiharaLars Eckmann
Jan 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dingzhi Wang, Raymond N DuBois
Jan 5, 2002·Hematology/oncology Clinics of North America·E J Dropcho
Oct 21, 2016·Oncoimmunology·Nathan B RobertsGraeme F Woodworth
May 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alba A BrandesMario Ermani
Aug 31, 1999·The Annals of Pharmacotherapy·H B NewtonL K McCoy
Apr 28, 2005·Expert Review of Neurotherapeutics·Carsten NiederMichael Molls
Oct 20, 2006·Journal of Neuro-oncology·Lynn G FeunNiramol Savaraj
Feb 20, 2003·British Journal of Cancer·B Fazeny-DörnerC Marosi
Apr 16, 2014·Journal of Neuro-oncology·Daniel J BratUNKNOWN AANS/CNS Joint Guidelines Committee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.