PMID: 11325488Apr 28, 2001Paper

Carboplatin and vinorelbine in untreated locally advanced and metastatic non-small cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
L HorvathJ F Bishop

Abstract

The aim of this study was to assess the activity and toxicity of carboplatin/vinorelbine combination chemotherapy in unresectable locally advanced and metastatic non-small cell lung cancer. Between April 1997 and June 1999 30 patients (22 M, eight F, median age 62) received treatment with carboplatin AUC 6 on day 1, and vinorelbine 25mg/m(2) on days 1, 8 and 15. Treatment was given every 28 days for six cycles unless progressive disease occurred. Twenty-three patients (77%) had stage IV disease, and seven (23%) stage IIIB. Ninety-three percent were WHO performance status 0-1. Twenty-three patients were fully assessable. Nine patients achieved partial responses (9/23, 39%) for an overall objective response rate of 9/30 (30%; 95% CI 15-49%). The median duration of response was 2.75 months (range 1-13 months). The median progression-free survival was 2 months and the median survival 5.25 months. The actuarial 1-year survival was 20%. The median number of cycles completed was two (range 1-6). Day 15 vinorelbine was administered in only 18% of cycles. The main toxicity was myelosuppression. WHO grade III/IV neutropenia was experienced in 50% of patients, however, there were only three episodes of febrile neutropenia. Eight patients ...Continue Reading

References

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Citations

Oct 9, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Philip C HoffmanEverett E Vokes
Jul 25, 2006·Expert Opinion on Investigational Drugs·Jamie S Mader, David W Hoskin
Jun 5, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Richard F RiedelJeffrey Crawford
Dec 5, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·I GauthierL Seymour

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