Carboplatin as a radiation sensitizer in locally advanced cervical cancer: a pilot study

Gynecologic Oncology
L I MuderspachF M Muggia

Abstract

Radiation therapy is the mainstay in treatment of locally advanced cervical carcinoma. Several chemotherapeutic agents have been used as radiation sensitizers in the treatment of cervical cancer in an effort to improve local response and survival. A prospective study was designed to evaluate carboplatin as a radiosensitizer in advanced cervical cancer. Standard radiotherapy techniques were used to treat patients with Stage IIA-IIIB cervical cancer. Intravenous carboplatin was administered twice weekly concurrent with external beam radiation. Of 22 evaluable patients, there were 19 complete responders of whom 15 remain alive: 11 patients were alive and disease free at last visit for a median duration of 15 months follow-up (range, 4-43 months) and 4 patients remain alive with disease for a median duration of 17 months (range, 3-55 months). Seven have died, one of whom was without evidence of disease. There were no treatment-related deaths and no grade 4 toxicity. The most significant adverse effect was hematologic resulting in four patients with grade 3 neutropenia or anemia. There were no fistulae or late gastrointestinal or genitourinary complications. This pilot study suggests that carboplatin administered with standard radia...Continue Reading

References

Dec 1, 1992·Archives of Otolaryngology--head & Neck Surgery·K Pekkola-HeinoR Grenman
Jan 1, 1991·Cancer Chemotherapy and Pharmacology·V Lira-PuertoF Muggia
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·G MilanoJ L Lagrange
Sep 1, 1989·Gynecologic Oncology·C D RunowiczR Byrnes

❮ Previous
Next ❯

Citations

Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
May 26, 2006·Radiation Oncology·Myrna CandelariaAlfonso Dueñas-Gonzalez
Jan 30, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Jialin YangJichuan Wang
Aug 6, 2008·Gynecologic Oncology·Lucía González-CortijoR Colomer
Feb 5, 2013·Journal of Medical Imaging and Radiation Oncology·George Au-YeungKailash Narayan
Aug 21, 2010·The Journal of Obstetrics and Gynaecology Research·Shigeki TakeshitaTakuya Ayabe
Dec 14, 2004·Gynecologic Oncology·Akira MitsuhashiSouei Sekiya
Sep 15, 2004·Critical Reviews in Oncology/hematology·Rosa TambaroSandro Pignata
May 14, 2005·Critical Reviews in Oncology/hematology·Krystyna Serkies, Jacek Jassem
Apr 2, 2002·Gynecologic Oncology·Charles J DuntonKelly Underhill
Nov 7, 2003·Cancer·Frederick B StehmanJ Taylor Wharton
Mar 9, 2010·Drugs·Alfonso Dueñas-GonzálezDéborah Martínez-Baños
Mar 4, 1998·Current Opinion in Obstetrics & Gynecology·P M DesRosiersM E Randall
Mar 6, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·J Dunst
Jun 3, 2021·Cancers·Ya-Hui ChenYi-Hsuan Hsiao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.