Carbopol-incorporated thermoreversible gel for intranasal drug delivery

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Prabagar BalakrishnanHyun-Jong Cho

Abstract

The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and intranasal absorption of fexofenadine hydrochloride (FXD HCl). The prepared gels were characterized by gelation temperature, viscoelasticity, and drug release profile. Thermoreversibility of P407/C934P gel was demonstrated by rheological studies. The incorporation of carbopol into P407 gel also reduced the amounts of drug released from the gel formulations (p < 0.05). In vivo pharmacokinetic results of the prepared gel formulations in rabbits (at 0.5 mg/kg dose) showed that the relative bioavailability of drug from P407/C934P gel was 11.3 and 2.7-fold higher than those of drug solution and P407 gel group, respectively. These findings suggested that developed thermoreversible gels could be used as promising dosage forms to improve intranasal drug absorption.

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Citations

Nov 14, 2015·Drug Discovery Today·Christina Karavasili, Dimitrios G Fatouros
Jun 3, 2016·Therapeutic Delivery·Darren SvirskisManisha Sharma
Jul 24, 2018·Drug Development and Industrial Pharmacy·Maha A MarzoukAmany I Abd El-Fattah
May 23, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yoon Tae GooYoung Wook Choi

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