Carbosilane dendrimers inhibit α-synuclein fibrillation and prevent cells from rotenone-induced damage

International Journal of Pharmaceutics
Katarzyna MilowskaMaria Bryszewska

Abstract

This study investigates the role of carbosilane dendrimers in fibrillation of α-synuclein and prevention of the mouse hippocampal cell (mHippoE-18) from rotenone-induced damage. Examining the interaction between carbosilane dendrimers and α-synuclein, we found that the dendrimers inhibit fibril formation. We also investigated cell viability, the production of reactive oxygen species (ROS), and mitochondrial membrane potential. mHippoE-18 cells were preincubated with carbosilane dendrimers before rotenone was added. All the dendrimers possess potential protection activity. Preincubation with dendrimers contributed to: increased viability, higher mitochondrial membrane potential, and reduced ROS level in cells. The probable mechanism of cell protection lies in the ability of dendrimers to capture rotenone by encapsulating or binding to its surface groups. The fact that dendrimers have prevention potential is important in the search for new pharmacological strategies against neurodegenerative disorders.

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Citations

Feb 9, 2017·Colloids and Surfaces. B, Biointerfaces·Dzmitry ShcharbinMaria Bryszewska
Apr 8, 2020·Chemistry : a European Journal·Paula OrtegaSara de Pablo
Jul 10, 2019·Future Medicinal Chemistry·Sylwia MichlewskaMaria Bryszewska
Jun 13, 2020·International Journal of Molecular Sciences·Sylwia MichlewskaMaria Bryszewska
Nov 4, 2020·Journal of Neurology·Jonathan BaskinSimon J G Lewis
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariapina D'OnofrioMichael Assfalg
Oct 17, 2017·Journal of Inorganic Biochemistry·Natalia Sanz Del OlmoF Javier de la Mata

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