Carboxyhemoglobin and methemoglobin levels as prognostic markers in acute pulmonary embolism

The American Journal of Emergency Medicine
Sotirios KakavasGeorgios Tatsis

Abstract

Carboxyhemoglobin (COHb) and methemoglobin (MetHb) levels have been associated with a poor outcome in patients with various pathological conditions including cardiovascular diseases. Our aim was to retrospectively assess the prognostic value of arterial COHb and MetHb in patients with acute pulmonary embolism (PE). We conducted a retrospective study of 156 patients admitted in a pulmonary clinic due to acute PE. Measured variables during emergency department evaluation that were retrospectively analyzed included the ratio of the partial pressure of oxygen in arterial blood to the fraction of oxygen in inspired gas, Acute Physiology and Chronic Health Evaluation II score, risk stratification indices, and arterial blood gases. The association between arterial COHb and MetHb levels and disease severity or mortality was evaluated using bivariate tests and logistic regression analysis. Arterial COHb and MetHb levels correlated with Acute Physiology and Chronic Health Evaluation II and pulmonary severity index scores. Furthermore, arterial COHb and MetHb levels were associated with troponin T and N-terminal pro-B-type natriuretic peptide levels. In univariate logistic regression analysis, COHb and MetHb levels were both significantly...Continue Reading

References

Jan 1, 1985·Respiration; International Review of Thoracic Diseases·T MallR Ritz
Oct 26, 1999·Annals of Emergency Medicine·R O WrightA D Woolf
Jan 3, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·B WeinbergerJ D Laskin
Nov 9, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jeffrey E SchmidtRobert F Tamburro
Jun 15, 2007·Critical Care Medicine·Daniel D MelleyTimothy W Evans
Sep 12, 2007·Antioxidants & Redox Signaling·Stefan W RyterAugustine M K Choi
Jun 30, 2009·Respiratory Care·Leo E Otterbein
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Atsushi IkedaNoriko Murase
Feb 26, 2010·Investigative Ophthalmology & Visual Science·Julia BiermannUlrich Goebel
Mar 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J YoshidaN Murase
Sep 22, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David SchibilskyUlrich Goebel
Mar 23, 2011·Circulation·Michael R JaffUNKNOWN American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology
Dec 29, 2011·Current Pharmaceutical Biotechnology·Simone Faller, Alexander Hoetzel
Jan 13, 2012·Critical Care : the Official Journal of the Critical Care Forum·Andreas S FazekasGeorg-Christian Funk
Dec 12, 2012·The American Journal of Emergency Medicine·Seref Kerem CorbaciogluAhmet Demircan
Dec 19, 2012·Journal of Emergencies, Trauma, and Shock·Youichi Yanagawa
Aug 1, 2015·European Heart Journal·S V KonstantinidesUNKNOWN Authors/Task Force Members

❮ Previous
Next ❯

Citations

May 28, 2015·The American Journal of Emergency Medicine·Sotirios KakavasGeorgios Tatsis
Jun 22, 2015·The American Journal of Emergency Medicine·Y Emrah EyiSukru Tekindur
Dec 28, 2016·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Begüm ErganNecati Gökmen
Dec 31, 2020·Journal of Clinical Medicine·Felix ScholkmannValentina Quaresima
Aug 1, 2021·International Journal of Clinical Practice·Buğra KergetMetin Akgün

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.