Carboxyhemoglobin levels as a predictor of risk for significant hyperbilirubinemia in African-American DAT(+) infants

Journal of Perinatology : Official Journal of the California Perinatal Association
David L SchutzmanR J Wong

Abstract

To compare the degree of hemolysis in a group of direct antiglobulin test (DAT) positive (pos) African-American (AA) infants as measured by carboxyhemoglobin corrected (COHbc) for carbon monoxide in ambient air to a similar group of DAT negative (neg) ABO incompatible infants and a group without blood group incompatibility. To determine if COHbc is a better predictor of significant hyperbilirubinemia than DAT status. A prospective study of 180 AA infants from the Well-Baby Nursery of an inner city community hospital, all of whose mothers were type O pos. Infants (60) were ABO incompatible DAT pos, 60 were ABO incompatible DAT neg and 60 were type O(+). Blood for COHbc was drawn at the time of the infants' initial bilirubin and the infants' precise percentile on the Bhutani nomogram was calculated. Mean COHbc of type O(+) infants was 0.76±0.21 and 0.78±0.24% for ABO incompatible DAT neg infants (P=0.63). Mean CoHbc for the ABO incompatible DAT pos infants was 1.03±0.41% (P<0.0001 compared with both type O and DAT neg infants). Optimal cutoff on the receiver operating characteristic curve for COHbc to determine the risk for being in the Bhutani curve high risk zone was COHbc >0.90% (area under the curve(AUC) 0.8113). This was sim...Continue Reading

References

Jul 4, 2001·Pediatrics·D K StevensonH Nakamura
Jul 3, 2004·Pediatrics·UNKNOWN American Academy of Pediatrics Subcommittee on Hyperbilirubinemia
Jul 6, 2010·The Journal of Pediatrics·Michael KaplanDavid K Stevenson
Dec 8, 2010·Archives of Pediatrics & Adolescent Medicine·David L SchutzmanShilpa Hundalani
Jun 7, 2011·Seminars in Perinatology·Tina M SlusherVinod K Bhutani
Aug 24, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·D K Stevenson
Oct 22, 2014·Pediatrics·Michael KaplanDavid K Stevenson
Jan 13, 2015·Seminars in Fetal & Neonatal Medicine·Vinod K Bhutani, Ronald Wong

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Citations

Dec 16, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·D L SchutzmanR J Wong
Jan 6, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·David L SchutzmanRonald J Wong
Mar 24, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·A L ElsaieD L Schutzman
Jul 15, 2021·The Journal of Pediatrics·Timothy M BahrRobert D Christensen

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