Carboxyhemoglobin levels in neonatal immune hemolytic jaundice treated with intravenous gammaglobulin

Vox Sanguinis
Z ErgazI Arad

Abstract

In order to examine the effect of intravenous immunoglobulin (IVIG) on the rate of hemolysis in immune hemolytic hyperbilirubinemia, we measured the carboxyhemoglobin levels of 5 newborn infants who were subjected to IVIG treatment. The pretreatment rate of hemolysis, in the 5 patients with isoimmune hemolytic jaundice (3 patients with Rh hemolytic disease of the newborn and 2 patients with ABO hemolytic disease of the newborn), as reflected by carboxyhemoglobin levels was higher than the rate of hemolysis in normal newborn infants. In 4 out of the 5 patients treated with IVIG, there was a rapid decline ( > 30%) of carboxyhemoglobin levels, a pattern which was different from that observed in normal newborn infants with no hemolytic jaundice and in 3 untreated patients with ABO hemolytic disease of the newborn. None of the treated patients required an exchange transfusion. Our preliminary results support the theory that the attenuation of jaundice observed following IVIG treatment in patients with immune hemolytic hyperbilirubinemia is caused, at least in part, by the reduction in hemolysis.

References

May 1, 1976·Acta paediatrica Scandinavica·T F NechelesT Valaes
Jul 1, 1987·The Journal of Pediatrics·G V MasseyH M Maurer
Jul 1, 1985·Archives of Disease in Childhood·M DeryckeG Tchernia
Feb 1, 1974·American Journal of Diseases of Children·E R AldenR P Wennberg
Jan 1, 1971·The Journal of Clinical Investigation·M J MaiselsC A Smith
Jan 1, 1993·Journal of Perinatal Medicine·Z Ergaz, I Arad
Nov 1, 1962·The Journal of Pediatrics·F A OSKI, A A ALTMAN
Jul 1, 1963·The Journal of Clinical Investigation·R F COBURNR E FORSTER

❮ Previous
Next ❯

Citations

May 1, 1997·Pediatric Research·M HaydeD K Stevenson
Jul 26, 2002·The Cochrane Database of Systematic Reviews·G S Alcock, H Liley
Mar 20, 2018·The Cochrane Database of Systematic Reviews·Carolien ZwiersHelen G Liley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Group Incompatibility

Blood group incompatibility between donor and recipient has been associated with poor transplant outcomes. Discover the latest research on blood group icompatibility here.