Carboxylated calixarenes bind strongly to CD69 and protect CD69(+) killer cells from suicidal cell death induced by tumor cell surface ligands

Bioorganic & Medicinal Chemistry
Karel BezouskaVladimír Kren

Abstract

We have recently identified a new class of high affinity ligands for CD69 leukocyte membrane receptor, carboxylated calixarenes. Of the three compounds investigated here, thiacalix[4]arene had the highest affinity for CD69 in direct binding assays, and proved to be the most specific inhibitor of CD69 identified so far in receptor precipitation and cellular activation experiments. Carboxylated calixarenes also proved effective at protection of CD69(high) lymphocytes from apoptosis triggered by a multivalent ligand or antibody. Thus, carboxylated calixarenes set a new paradigm for noncarbohydrate ligands for CD69 making them attractive for protection of killer cells in combined animal tumor therapies.

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Citations

May 10, 2011·Chemical Communications : Chem Comm·Florent Perret, Anthony W Coleman
Jan 22, 2014·International Journal of Molecular Sciences·Daniel RozbeskýOlivier Renaudet
Mar 1, 2012·Drug and Chemical Toxicology·Bahram Mokhtari, Kobra Pourabdollah
Oct 4, 2012·Chemical Society Reviews·Satish Balasaheb Nimse, Taisun Kim

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