Carboxymethyl cellulose is a superior polyanion to dextran sulfate in stabilizing and enhancing the solubility of amorphous drug-polyelectrolyte nanoparticle complex

International Journal of Biological Macromolecules
Bingxue Dong, Kunn Hadinoto

Abstract

Amorphous drug-polyanion nanoplex represents an effective solubility enhancement strategy of weakly-basic poorly-soluble drugs. While dextran sulfate (DXT) was chosen in most studies as the polyanion for nanoplex formation, drug-DXT nanoplex demonstrated poor long-term physical stability for drugs with high crystallization propensity, such as ciprofloxacin (CIP). Herein we hypothesized that amorphous form stability of CIP nanoplex could be improved by substituting DXT with carboxymethyl cellulose (CMC) known for its crystallization inhibiting activity. The optimal preparation condition of the CIP-CMC nanoplex was determined by investigating the effects of CMC/CIP charge ratio and pH on the resultant nanoplex's physical characteristics and preparation efficiency. At the optimal condition, the CIP-CMC nanoplex possessed size, zeta potential, and CIP payload of approximately 200 nm, -49 mV, and 76%, respectively. Its preparation was highly efficient with CIP utilization rate and overall yield of roughly 89% and 46%, respectively. Compared to the CIP-DXT nanoplex, the CIP-CMC nanoplex was larger and with higher CIP payload attributed to CMC's higher chain stiffness. The CIP-CMC nanoplex exhibited superior physical stability after t...Continue Reading

References

Jul 27, 2001·International Journal of Pharmaceutics·K MoserR H Guy
Nov 12, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ray-Neng ChenMing-Thau Sheu
Dec 9, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Thierry Delair
Nov 5, 2011·Journal of Colloid and Interface Science·Wean Sin Cheow, Kunn Hadinoto
Mar 24, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Wean Sin Cheow, Kunn Hadinoto
Oct 27, 2012·Chemical Society Reviews·David T ManallackDavid K Chalmers
Jul 15, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Minh Hiep NguyenKunn Hadinoto
Dec 22, 2015·International Journal of Pharmaceutics·Gheorghe JuncuSorin Ion Jinga
Feb 3, 2016·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Guoshun ZhangYang Lu
Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Dhiraj R SikwalThirumala Govender
Apr 14, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Chandrakantsing Vijaysing Pardeshi, Veena Shailendra Belgamwar
Apr 26, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Shrawan BaghelNiall J O'Reilly
May 4, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Minh-Hiep NguyenKunn Hadinoto
Aug 16, 2016·International Journal of Pharmaceutics·Nazende Günday TüreliMarc Schneider
Nov 7, 2016·Journal of Pharmaceutical Sciences·Rajan Jog, Diane J Burgess
Mar 30, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Qun-Li LeiRan Ni
Sep 11, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Li Ming LimKunn Hadinoto
Sep 19, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hanah MesallatiLidia Tajber
Jan 27, 2018·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Miriam ColomboRoland Bodmeier
Oct 26, 2018·International Journal of Pharmaceutics·Rajan Jog, Diane J Burgess
Jan 15, 2019·International Journal of Pharmaceutics·Daniel HassanThirumala Govender

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