Carboxymethyl chitosan as an antifungal agent on gauze

International Journal of Biological Macromolecules
Mardiyah KurniasihRatna Stia Dewi

Abstract

Chitosan is a biopolymer that has antifungal activity against C. albicans. Chemical modification of chitosan can provide it with new functional properties for a wide range of biological and biomedical applications. Carboxymethyl chitosan is a derivative of chitosan obtained by etherification of alkaline chitosan with monochloroacetic acid. Carboxymethyl chitosan has a higher solubility than chitosan; therefore it is more readily applicable for use in various fields. Chitosan also has antifungal activity against C. albicans. This study evaluated carboxymethyl chitosan as a gauze-coating material to be used for its antifungal properties. This study also optimized the coating process. Gauze was coated with carboxymethyl chitosan then characterized by Fourier Transform Infra-Red Spectrophotometer (FTIR), X-ray diffraction and scanning electron microscopy (SEM). The antifungal activities of gauze-coated samples were then tested by the diffusion method. The results show that the optimum conditions for the process of coating gauze with carboxymethyl chitosan are dipping ten times at a concentration of 1% for 50 s. Antifungal activities of carboxymethyl chitosan-coated gauze as measured by the diameter of the growth inhibition area are...Continue Reading

Citations

Apr 19, 2020·Applied Microbiology and Biotechnology·Qian YeYishan Zheng
Nov 14, 2019·Nanomaterials·Rajiv Gandhi PackirisamyDhanasekaran Vikraman
Jan 17, 2020·International Journal of Molecular Sciences·Wenqian WangKai Zhao
Oct 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristina MoraruVasile Ostafe
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana CardosoEugénia Pinto
Mar 3, 2021·International Journal of Biological Macromolecules·Lijie WeiZhanyong Guo
Sep 30, 2018·International Journal of Biological Macromolecules·Zahra Shariatinia

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