Carboxymethyl pachyman (CMP) reduces intestinal mucositis and regulates the intestinal microflora in 5-fluorouracil-treated CT26 tumour-bearing mice

Food & Function
Canhong WangLi Cao

Abstract

The compound 5-fluorouracil (5-FU) is the first choice chemotherapeutic agent for the treatment of colorectal cancer (CRC), but intestinal mucositis is a primary limiting factor in anticancer therapy. There is currently no broadly effective targeted treatment to cure this side effect. Carboxymethylated pachyman (CMP) is a polysaccharide that is modified from the structure of pachyman isolated from Poria cocos (Chinese name: Fu Ling). Meanwhile, recent studies have shown that CMP exhibits immune regulatory, anti-inflammatory and antioxidant activities. Therefore, the purpose of this study was to evaluate the intestinal protective effect of CMP in 5-FU-treated CT26 tumour-bearing mice and to further explore its underlying mechanism(s) of action. Initially, a CT26 colon carcinoma xenograft mice model was established. The colon length, colon tissue injury, intestinal flora, short-chain fatty acids (SCFAs) and indicators linked to inflammation, antioxidation and apoptosis were then measured. Our results showed that CMP in combination with 5-FU reversed intestinal shortening (p < 0.01) and alleviated 5-FU-induced colon injury (p < 0.001) via suppression of ROS production; increasing the levels of CAT, GSH-Px and GSH; decreasing expre...Continue Reading

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Citations

Sep 3, 2020·Chinese Journal of Integrative Medicine·Ying-Xin SunBin Yu
Dec 12, 2018·Frontiers in Pharmacology·Wuwen FengCheng Peng
Oct 20, 2020·Frontiers in Pharmacology·Anzheng NieChunsheng Zhu
Dec 10, 2020·Journal of Gastroenterology and Hepatology·Sedigheh Taghinezhad-SXiangsheng Fu
May 1, 2021·Nutrients·Thaísa Agrizzi VeredianoElad Tako
Aug 10, 2021·Frontiers in Physiology·Karien Sauruk da SilvaDaniele Maria-Ferreira

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Methods Mentioned

BETA
xenograft
electrophoresis
PCR
xenografts
PCA

Software Mentioned

SPSS17
Image
Pro Plus

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