Carboxymethylcellulose/MOF-5/Graphene oxide bio-nanocomposite as antibacterial drug nanocarrier agent

BioImpacts : BI
Zahra KarimzadehHassan Namazi

Abstract

Introduction: In recent years, more attention was dedicated to developing new methods for designing of drug delivery systems. The aim of present work is to improve the efficiency of the antibacterial drug delivery process, and to realize and to control accurately the release. Methods: First, graphene oxide (GO) was prepared according to the modified Hummers method then the GO was modified with carboxymethylcellulose (CMC) and Zn-based metal-organic framework (MOF-5) through the solvothermal technique. Results: Performing the various analysis methods including scanning electron microscope (SEM), X-ray diffraction (XRD), EDX, Fourier transform infrared (FTIR) spectroscopy and Zeta potentials on the obtained bio-nanocomposite showed that the new modified GO has been prepared. With using common analysis methods the structure of synthesized materials was determined and confirmed and finally, their antibacterial behavior was examined based on the broth microdilution methods. Conclusion: Carboxymethylcellulose/MOF-5/GO bio-nanocomposite (CMC/MOF-5/GO) was successfully synthesized through the solvothermal technique. Tetracycline (TC) was encapsulated in the GO and CMC/MOF-5/GO. The drug release tests showed that the TC-loaded CM...Continue Reading

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Citations

Apr 29, 2020·Materials·Maria Luisa SaladinoMagdalena Wawrzyńska
Sep 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gongsen ChenJian Ni
Apr 28, 2021·International Journal of Biological Macromolecules·Roshanak TarrahiFarbod Ebadi Fard Azar
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Aug 26, 2021·Critical Reviews in Microbiology·Christian Rafael QuijiaMarlus Chorilli
Sep 23, 2021·Scientific Reports·Saleheh Sanaei-RadSeyyed Mohammad Hossein Razavian

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Methods Mentioned

BETA
dynamic light scattering
X-ray

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