PMID: 7023523Aug 1, 1981Paper

Carcinoembryonic antigen and prognosis after radical surgery for lung cancer: immunocytochemical localization and serum levels

British Journal of Cancer
C H FordC E Newman

Abstract

Eighty-two per cent of tumour sections from 105 patients with lung cancer showed positive immunocytochemical localization of an anti-carcinoembryonic antigen (CEA) immunoglobulin free of antibody to normal cross-reacting antigen (NCA). The highest incidence was found in adenocarcinomas, and no association between staining and disease stage was found. There was a relationship between positive-staining tumours and preoperative and postoperative serum CEA levels of greater than or equal to 20 ng/ml, but the high incidence of CEA+, less than 20 ng/ml serum patients indicated that immunocytochemical localization was of little value in selecting patients for sequential serum monitoring. Staining for CEA was not prognostic but a preoperative serum CEA levels greater than or equal to 20 ng/ml was associated with a poor prognosis in patients undergoing radical surgery for lung cancer (P = 0.043). this prognostic effect of CEA was seen mainly in patients whose tumours showed the greatest immunocytochemical localization (P = 0.017) and in Stage III patients (P = 0.04).

Citations

Mar 1, 1988·Journal of Clinical Pathology·F MacdonaldJ Crocker
Jan 1, 1983·Cancer Metastasis Reviews·D J Laurence, A M Neville
Jun 19, 2013·The Korean Journal of Thoracic and Cardiovascular Surgery·Seokkee LeeKyung Young Chung
Feb 24, 2017·Surgery Today·Haruhiko Nakamura, Toshihide Nishimura
Sep 1, 1984·Histopathology·H Loosli, J Hurlimann
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·R WachnerS von Kleist
Feb 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guofen SongDi Zhang
Jul 1, 1987·European Journal of Cancer & Clinical Oncology·R A Stahel, G Martz

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