Jan 1, 1977

Carcinoembryonic antigen in amniotic fluid

Acta Medica Scandinavica
H GadlerE Malmqvist

Abstract

Carcinoembryonic antigen (CEA), a substance which is known to occur in high amounts in the fetal gut and also in certain tumors of the gastrointestinal tract, has been demonstrated in amniotic fluids from different stages of pregnancy. Radioimmunoassays of CEA in amniotic fluids of 91 normal pregnancies showed a decrease from a mean of 53 ng/ml at 19 weeks to 25 ng/ml at the end of gestation. The CEA activity in amniotic fluid was eluted in the same volume as a standard 125I-CEA on a Sephadex G200 column. Amniotic fluid therefore contains CEA similar in molecular weight to the CEA purified from liver metastases of colonic cancer. Among 17 cases of abnormal pregnancies, CEA elevations were observed in five with anomalous fetuses.

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Mentioned in this Paper

Autosomal Chromosome Disorders
Fetal Distress
Neoplasms
Carcinoembryonic Antigen
Autosome Abnormalities
Pregnancy Complications
Amniotic Fluid Index
Radioimmunoassay
Colonic Neoplasms
Molecular Sieve Chromatography

About this Paper

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