Carcinoembryonic antigen induction of IL-10 and IL-6 inhibits hepatic ischemic/reperfusion injury to colorectal carcinoma cells

International Journal of Cancer. Journal International Du Cancer
J M JessupPeter Thomas

Abstract

Tumor cells cause ischemia/reperfusion (I/R) injury as they arrest within the hepatic microvasculature with the production of nitric oxide (NO) and reactive oxygen species (ROS) that kill both host liver and implanting tumor cells. Carcinoembryonic antigen (CEA) both facilitates the survival of experimental metastasis to nude mouse liver by weakly metastatic human colorectal carcinomas (CRCs) and induces the release of the proinflammatory cytokine IL-6. We hypothesized that CEA also stimulates the release of the antiinflammatory cytokine IL-10 causing inhibition of the toxicity of hepatic I/R injury and indirect stimulation of tumor cell colonization of the liver. Intravenous injection of CEA produced more than 1 ng/ml of IL-10 in the systemic circulation within 1 hr which subsided by 8 hr. The IL-10 response is specific to CEA since the pentapeptide sequence in CEA that binds to the CEA receptor stimulated isolated Kupffer cells to produce IL-10. IL-10, but not IL-6, increased the survival of weakly metastatic CRC cocultured with ischemic-reoxygenated liver fragments but did not affect the survival of CRC exposed to oxidative stress in the absence of any host cells. CEA, IL-6 and IL-10 pretreatment reduced expression of iNOS b...Continue Reading

References

Dec 1, 1975·Biochemical and Biophysical Research Communications·P Thomas, D A Hems
Mar 7, 1990·Journal of the National Cancer Institute·R B HostetterJ M Jessup
Sep 14, 1990·Biochemical and Biophysical Research Communications·C A TothP Thomas
Jul 9, 1993·International Journal of Cancer. Journal International Du Cancer·E Barbera-Guillem, L Weiss
Oct 1, 1996·Archives of Biochemistry and Biophysics·A Gangopadhyay, P Thomas
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshidomeA B Lentsch
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O Le MoineJ Devière
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N G FrangogiannisM L Entman
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R C BastUNKNOWN American Society of Clinical Oncology Tumor Markers Expert Panel
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S P JonesD J Lefer
Jun 15, 2001·The Journal of Biological Chemistry·O V BajenovaP Thomas
Dec 12, 2001·Kidney International·J DengR A Star
Jan 15, 2002·American Journal of Physiology. Cell Physiology·Chuanyu Li, Robert M Jackson
Jan 25, 2002·Annals of Surgery·Hitesh PatelTimothy G Allen-Mersh
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Aug 16, 2002·Transplant Immunology·Annette Boehler
Nov 15, 2002·Molecular and Cellular Endocrinology·Zoran CuligAlfred Hobisch

❮ Previous
Next ❯

Citations

Aug 2, 2013·Cancer Metastasis Reviews·Nicole Beauchemin, Azadeh Arabzadeh
Jul 23, 2005·Clinical & Experimental Metastasis·J Milburn JessupL M Laguinge
Mar 25, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Fernando Vidal-Vanaclocha
Aug 27, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Fernando Vidal-Vanaclocha
Mar 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthew R DallasKonstantinos Konstantopoulos
Oct 2, 2007·Clinical & Experimental Metastasis·Fayth L MilesCarlton R Cooper
Feb 20, 2007·Clinical Biochemistry·Vassiliki MatzarakiGeorge Baltopoulos
Jun 8, 2017·Gastroenterology Research and Practice·Joo Han Lee, Seong-Wook Lee
Jun 29, 2016·World Journal of Gastroenterology : WJG·Martin TobiDaniel Ezekwudo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.