Carcinoembryonic antigen levels correlated with advanced disease in medullary thyroid cancer

Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale
Sena TurkdoganRichard J Payne

Abstract

Medullary thyroid cancer (MTC) cells are capable of secreting various tumor markers including calcitonin and carcinoembyronic antigen (CEA). The purpose of this study is to determine whether abnormal CEA levels may be used as a tumor marker to predict the severity of disease in MTC. A retrospective analysis was completed for 33 patients with MTC who had preoperative serum CEA levels. Univariate and multivariate analyses were used to quantify the relationship between serum CEA levels and tumor stage and prognosis. On multivariate analysis, elevated preoperative CEA levels were significantly associated with the size and stage of tumor, distant metastasis, decreased biochemical cure, and mortality. There was a significant association between tumor size greater than 37 mm and elevated CEA levels (> 271 ng/ml). There was also a positive correlation with increased cancer stage (> 377 ng/ml), distant metastasis (> 405 ng/ml), and contralateral compartment location of lymph node metastasis (> 162 ng/ml). When pre-operative CEA levels are > 500 ng/ml, patient mortality was 67%. In this study, both pre-operative calcitonin and CEA levels were significantly correlated with the extent of disease in MTC. While calcitonin has a linear relati...Continue Reading

References

Sep 29, 1994·The New England Journal of Medicine·R D Utiger
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Georgios KaranikasChristian Pirich
Jan 22, 2008·American Journal of Surgery·Roy Phitayakorn, Christopher R McHenry
Dec 17, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Giuseppe CostanteSebastiano Filetti
Mar 27, 2010·The Journal of Clinical Endocrinology and Metabolism·Andreas Machens, Henning Dralle
Jul 23, 2013·Indian Journal of Endocrinology and Metabolism·Rafael Loch BatistaMalebranche Berardo C Cunha-Neto
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Samuel A WellsUNKNOWN American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Oct 27, 2015·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Yoon Ju BaeJuergen Kratzsch

❮ Previous
Next ❯

Citations

Apr 22, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bayan AlzumailiRonald A Ghossein
Jul 22, 2020·Proceedings of the National Academy of Sciences of the United States of America·Angela M CarterJames A Bibb
Feb 6, 2020·Current Opinion in Otolaryngology & Head and Neck Surgery·Jonathan Mark FusseyJoel A Smith
Sep 21, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Felix EckeltJuergen Kratzsch
Nov 4, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bin XuRonald A Ghossein

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
dissection
dissections

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.