Carcinoembryonic antigen surge in metastatic colorectal cancer patients responding to irinotecan combination chemotherapy

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Xin AnYu-Hong Li

Abstract

Oxaliplatin (OXA)-induced carcinoembryonic antigen (CEA) surge was reported to be associated with a clinical benefit. The aim of this study was to investigate the phenomenon of CEA surge in irinotecan-based chemotherapy. We retrospectively reviewed 132 patients with metastatic colorectal cancer treated with irinotecan-based chemotherapy. Incidence of a CEA surge and chemotherapy efficacy were investigated. Eleven of 99 eligible patients (11.1%) had CEA surges. None of the 11 patients showed progressive disease (four had a partial response, seven had stable disease). A CEA surge can be induced by irinotecan-based chemotherapy. An early increase in CEA after irinotecan-based chemotherapy does not usually indicate progression of disease and failure of therapy, and should not lead to a change of chemotherapy.

References

Jan 1, 1986·Annals of Internal Medicine·R H Fletcher
Oct 18, 2003·Journal of Cancer Research and Clinical Oncology·Shunroh OhtsukasaKenichi Sugihara
Dec 6, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christophe TournigandAimery de Gramont
Mar 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Angelo AquinoEnzo Bonmassar
Jun 12, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·V Trillet-LenoirJ P Bleuse
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 4, 2005·The New England Journal of Medicine·Jeffrey A Meyerhardt, Robert J Mayer
Oct 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gershon Y LockerUNKNOWN ASCO
Apr 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard B SaltzJim Cassidy

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Citations

Jan 24, 2019·International Journal of Colorectal Disease·Giuseppe Antonio CollocaDomenico Guarneri

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