Carcinoembryonic antigen transgenic mouse models for immunotherapy and development of cancer vaccines

Current Protocols in Immunology
Malaya Bhattacharya-ChatterjeeSunil K Chatterjee

Abstract

The goal of cancer therapy remains as the long-term eradication of tumor cells without adverse effects on normal tissue. Conventional approaches utilizing chemotherapy and radiotherapy are limited by both their toxicity and lack of specificity. In recent years, investigators have carried out several studies designed to evaluate whether human tumor-associated antigens (TAAs) can be exploited as targets for immunotherapy, specifically for human cancer vaccine development. A major limitation in immunotherapy studies of human cancer is the general lack of appropriate preclinical models. Clinical studies can be difficult to implement, particularly when a clear understanding of the potential efficacy, limitation, and safety of an immunotherapeutic strategy is not available from relevant animal investigations. However, mice carrying a transgene for a human tumor self-antigen may provide a more acceptable experimental model in which knowledge about immunotherapeutic strategies aiming at the TAA of interest can be enhanced prior to initiating clinical trials. Since the different strategies in experimental immunotherapy of cancer have been directed to activate different immune system components, a variety of transgenic mouse models have ...Continue Reading

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C T GuyW J Muller
Oct 1, 1991·British Journal of Cancer·T HasegawaK Shimokata
Jan 1, 1991·Journal of Clinical Laboratory Analysis·J A ThompsonW Zimmermann
Jan 1, 1985·Critical Reviews in Oncology/hematology·J E Shively, J D Beatty
Oct 1, 1995·Journal of Hematotherapy·I A Heijnen, J G Van de Winkel
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·C WeiJ G Frelinger
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·J A ThompsonW Zimmermann
May 1, 1997·The Journal of Surgical Research·Z YuJ D Ellenhorn
Apr 3, 1998·Annals of Surgical Oncology·T M McCartyJ D Ellenhorn
May 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G RiethmüllerR Pichlmayr
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J GongD Kufe
Jun 25, 1998·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G SzalaiF J Primus
Jul 7, 1998·The Journal of Experimental Medicine·F FallarinoT F Gajewski
Oct 31, 1998·Current Opinion in Immunology·D M Pardoll, S L Topalian
Dec 22, 1998·The Journal of Experimental Medicine·S A Kalams, B D Walker
Mar 2, 1999·The Journal of Experimental Medicine·R E ToesC J Melief
Apr 29, 1999·Annals of Medicine·D Herlyn, B Birebent
Sep 29, 1999·Cancer Immunology, Immunotherapy : CII·E Gilboa
Oct 6, 1999·Current Opinion in Biotechnology·S Schlesinger, T W Dubensky
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K A FoonM Bhattacharya-Chatterjee
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·M J Morris, G J Bosl
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Jul 6, 2000·Advances in Immunology·C J MeliefR Offringa
Jul 19, 2000·Current Opinion in Immunology·S GurunathanR A Seder
Aug 18, 2000·Cancer Immunology, Immunotherapy : CII·S MizobataF J Primus
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P MukherjeeS J Gendler
Feb 27, 2001·Journal of Immunological Methods·M L Penichet, S L Morrison
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·R W WilkinsonS J Mather

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Citations

Feb 3, 2018·Human Gene Therapy·Elizabeth Louise Siegler, Pin Wang
Jan 6, 2011·FEMS Microbiology Reviews·Manish SadaranganiScott D Gray-Owen
Jan 16, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tara S AbrahamAdam E Snook
Dec 20, 2014·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Michiko HaraoLaszlo G Radvanyi
Sep 13, 2011·Nature Nanotechnology·Nam-Hyuk ChoSeung-Yong Seong
Mar 17, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·L C CutmoreJ F Marshall

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