Aug 22, 1975

Carcinofetal alterations in glucosamine-6-phosphate synthetase

Annals of the New York Academy of Sciences
S Tsuiki, T Miyagi


The levels of glucosamine-6-phosphate synthetase in various rat tissues including those undergoing differentiation or regeneration revealed that the enzyme is related to tissue proliferation and differentiation. In the liver upon neoplastic transformation, the level of glucosamine 6-phosphate synthetase rises and the liver form of the enzyme having a pI at 5.0 is replaced by a form with a pI of 4.1. Since the latter form has also been found present in whole embryos (12- and 14-day) and brain, the molecular alterations of glucosamine-6-phosphate synthetase in liver neoplasia can be considered to be carcinofetal.

Mentioned in this Paper

Fetal Structures
Tissue Specificity
Phosphate Measurement
Neoplastic Disease
Cell Differentiation Process
Liver Diseases

About this Paper

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