Sep 3, 2016

Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice

Oncotarget
Zhengxue LiuFang Liu

Abstract

Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. In this report, we show that DMBA (7,12-dimethylbenz[a]anthracene), a chemical carcinogen, induces mammary tumor formation at a significantly higher frequency in the Smad3 heterozygous mice than in the Smad3 wild type mice. This is the first genetic evidence showing that Smad3 inhibits mammary tumor formation in a mouse model. Our findings support the notion that Smad3 has important tumor suppressor function for breast cancer.

Mentioned in this Paper

Tumor Promoters
Study
Tumor Suppressor Genes
9,10-Dimethyl-1,2-benzanthracene
Mammary Tumorigenesis
Functioning Endocrine Neoplasm
FXYD3
Cell Culture Techniques
Anthracene
Smad3 Protein

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