Carcinogenesis driven by bone marrow-derived stem cells

Contributions to Microbiology
T DittmarB Niggemann

Abstract

The overall mechanism of bone marrow-derived stem cell (BMDC) trans-differentiation seems to be simple: BMDCs trans-differentiate as referred to the blueprint, which is given by the tissue itself. Thereby, the blueprint can be the local tissue micro-environment (defined by the tissue-specific cytokine, chemokine, adhesion molecule pattern, etc.), it can be a single cell (cell fusion), or it can be a combination of both. In fact stem cell trans-differentiation is a complex not yet fully understood process. In between the start- and stop-points of transdifferentiation several gene reprogramming steps have to occur in a sequential step-by-step manner, for which a defined set of instructions is a prerequisite to ensure an accurate transdifferentiation. However, a recent study indicated that the ability of BMDCs - to adopt tissue function by reading its blueprint - seems to be a double-edged sword since BMDCs that have received a faulty blueprint, provided by chronically inflamed tissue, trans-differentiated into a neoplastic phenoytpe. Here, we review the importance of an accurate blueprint for BMDC trans-differentiation and discuss a model showing that BMDCs might contribute to overall tumor development due to recruitment to tumor...Continue Reading

Citations

Dec 22, 2006·Nature Clinical Practice. Oncology·JeanMarie Houghton
Mar 21, 2007·Journal of Cellular and Molecular Medicine·Denitsa DochevaMatthias Schieker
Nov 29, 2007·Annals of Surgical Oncology·Xiong-Zhi Wu
Mar 29, 2008·Gene Therapy·K S AboodyM K Danks
Apr 8, 2010·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yoshiro SaikawaYuko Kitagawa
Mar 12, 2020·International Journal of Molecular Sciences·Jessica DörnenThomas Dittmar

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