Carcinogenesis in relation to the stem-cell-mutation hypothesis

Differentiation; Research in Biological Diversity
S Kondo

Abstract

From reports on fish, mice, rats, and humans, it can be concluded that at early developmental stages, especially stages before organogenesis, vertebrates are resistant to the induction of tumors by carcinogens. This conclusion and results on the molecular biology of chemical carcinogenesis in mice support the hypothesis that carcinogenesis of an organ is initiated by mutation of its stem cells formed during organogenesis. Convincing support for the existence of mutations that cause development of tumors is that heritable tumors are induced in mice and Drosophila by exposure of germ cells to radiation and chemicals. Various lines of evidence support the notion that tumor genes, which increase the predisposition of their carriers to develop tumors, are at least partly regulatory mutations. In this paper, the interrelation of tumorigenesis and teratogenesis, the high susceptibility of growing or regenerating organs to induction of tumors by carcinogens, and the latent period of induced neoplasms are discussed in relation to the stem-cell-mutation hypothesis.

References

May 1, 1978·Journal of the National Cancer Institute·J H WalesT A Eisele
Jan 1, 1978·Advances in Cancer Research·F M Burnet
Jan 1, 1978·Annual Review of Genetics·M NagaoT Matsushima
Jan 1, 1979·Annual Review of Biochemistry·P C HanawaltC A Smith
Jan 1, 1979·Differentiation; Research in Biological Diversity·L G Lajtha
Jan 1, 1979·Nouvelle Revue Française D'hématologie·L G Lajtha
Nov 1, 1978·Cell·C S PottenJ Cairns
Dec 1, 1976·Bacteriological Reviews·E M Witkin
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Jan 1, 1975·Advances in Cancer Research·M B Shimkin, G D Stoner
Mar 15, 1972·International Journal of Cancer. Journal International Du Cancer·F J RoeE Hecker
Jan 29, 1981·Nature·J Cairns
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A R KennedyJ B Little
Nov 1, 1981·Scientific American·P Howard-Flanders
Jan 1, 1955·Advances in Cancer Research·M B SHIMKIN
Apr 6, 1957·British Medical Journal·M BURNET
Aug 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·A C UPTONE P SNIFFEN
Jun 1, 1962·British Journal of Cancer·A W POUND
Mar 1, 1957·Genetics·L B Russell, M H Major

❮ Previous
Next ❯

Citations

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·K Aterman
Nov 10, 2006·Cancer Cell International·Rengaswami RajaramanSelva R Rajaraman
Apr 22, 2008·Stem Cell Reviews·James E Trosko
May 1, 1985·European Journal of Cancer & Clinical Oncology·Y L LuM Vandeputte
Sep 30, 2000·Experimental Cell Research·N D KimK H Clifton
Apr 13, 2001·Molecular Carcinogenesis·J E Trosko
Jul 1, 1988·Japanese Journal of Cancer Research : Gann·S Kondo
Jul 4, 2002·Annals of the New York Academy of Sciences·Giuseppe CarrubaLuigi Castagnetta
Jan 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S Kondo
Jan 1, 2008·Clinical Medicine. Oncology·P Taupin
Oct 9, 1987·Science·R Holliday

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.