PMID: 9447652Feb 3, 1998Paper

Carcinogenesis models for risk assessment

Statistical Methods in Medical Research
A Kopp-Schneider

Abstract

This article provides an overview of different types of carcinogenesis models and discusses their use for risk assessment. One class of model, the multistage model, is especially suited for risk assessment purposes because it uses biological information about the process of carcinogenesis and the quantities of interest, such as time to tumour and number and size distribution of premalignant tumours, can be derived explicitly, allowing for standard statistical techniques to be used. The mathematical methods necessary for the treatment of multistage models are developed and the application of multistage models in risk assessment is discussed.

References

Jul 1, 1978·Journal of the National Cancer Institute·S H Moolgavkar
Nov 1, 1977·American Journal of Epidemiology·A S Whittemore
Apr 15, 1992·Journal of the National Cancer Institute·S H Moolgavkar, E G Luebeck
Oct 1, 1992·Journal of Clinical Epidemiology·S MatsushitaY Toyokura
Jun 1, 1992·Carcinogenesis·A Kopp-Schneider, C J Portier
Sep 1, 1991·Risk Analysis : an Official Publication of the Society for Risk Analysis·R L KodellJ M Zielinski
Sep 1, 1991·Risk Analysis : an Official Publication of the Society for Risk Analysis·C J Portier, A Kopp-Schneider
Mar 1, 1989·Risk Analysis : an Official Publication of the Society for Risk Analysis·C C Brown, K C Chu
Jun 1, 1989·Risk Analysis : an Official Publication of the Society for Risk Analysis·A DewanjiS H Moolgavkar
Sep 1, 1988·Risk Analysis : an Official Publication of the Society for Risk Analysis·S H MoolgavkarD J Venzon
Dec 1, 1988·Risk Analysis : an Official Publication of the Society for Risk Analysis·D J Murdoch, D Krewski
Dec 1, 1987·Environmental Health Perspectives·C J Portier
Mar 1, 1987·Risk Analysis : an Official Publication of the Society for Risk Analysis·T W ThorslundG Charnley
Oct 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·K S Crump
Jun 1, 1981·Journal of the National Cancer Institute·S H Moolgavkar, A G Knudson
Apr 1, 1995·Regulatory Toxicology and Pharmacology : RTP·D G BarnesH L Spitzer
Dec 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·K S Crump
Dec 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·A Kopp-SchneiderC D Sherman
Dec 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·Q Zheng
Dec 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·S H Moolgavkar
Dec 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·K S Crump
Apr 1, 1994·Mathematical Biosciences·N Becker, W Rittgen
Apr 1, 1994·Mathematical Biosciences·A Kopp-Schneider, C J Portier
Jan 1, 1993·Mathematical Biosciences·L B Klebanov Yakovlev AYu
May 1, 1996·Toxicology and Applied Pharmacology·C J PortierG Lucier
Jul 15, 1996·Mathematical Biosciences·C J PortierC D Sherman
May 1, 1996·Radiation and Environmental Biophysics·W F Heidenreich
Oct 1, 1996·Risk Analysis : an Official Publication of the Society for Risk Analysis·L G Hanin, Yakovlev AYu
Mar 1, 1953·British Journal of Cancer·C O NORDLING
Mar 1, 1954·British Journal of Cancer·P ARMITAGE, R DOLL
Sep 1, 1951·Cancer·J C FISHER, J H HOLLOMON

❮ Previous
Next ❯

Citations

Jul 28, 2005·International Journal of Epidemiology·Lutz Edler, Annette Kopp-Schneider
Mar 17, 2012·Journal of the National Cancer Institute·Suresh H MoolgavkarEric J Feuer
Dec 17, 2014·International Journal of Epidemiology·Odd O AalenSteinar Tretli
Feb 3, 1998·Statistical Methods in Medical Research·C Portier, H el Masri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.