PMID: 8599732Mar 1, 1996Paper

Carcinogenesis of cutaneous malignancies

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
R A Buzzell

Abstract

Over the past several years significant progress has been made in identifying the cellular and biochemical mechanisms underlying carcinogenesis. This review summarizes recent advances that have helped clarify the process of malignant transformation in cutaneous tumors. Ultraviolet radiation-induced mutations in the p53 tumor suppressor gene and human papilloma virus inhibition of the p53 and retinoblastoma tumor suppressor gene products appear to play significant roles in the development of many cutaneous squamous cell carcinomas. Studies of patients with the nevoid basal cell carcinoma syndrome suggest the existence of an additional regulatory gene that may be involved in the development of basal cell carcinomas. Carcinogenesis is multistep process involving genetic and epigenetic alterations to specific proto-oncogene and tumor suppressor gene products that progressively release the cell from normal controlled growth and replication.

References

Jul 1, 1976·Journal of the National Cancer Institute·M L Kripke, M S Fisher
Nov 1, 1975·Journal of the National Cancer Institute·R G Freeman
Mar 7, 1992·Lancet·P A FarndonM W Kilpatrick
Jan 1, 1992·Cancer Treatment and Research·C A Finlay
Dec 1, 1992·Histopathology·M BarbareschiS Boi
Nov 1, 1992·Environmental Health Perspectives·M W AndersonR M Maronpot
Aug 21, 1992·Cell·B Vogelstein, K W Kinzler
Jul 2, 1992·Nature·D P Lane
Nov 22, 1991·Science·R A Weinberg
Nov 22, 1991·Science·S A Aaronson
Nov 22, 1991·Science·H zur Hausen
Jan 1, 1991·Molecular Carcinogenesis·W E PierceallH N Ananthaswamy
Jan 25, 1991·Cell·L C CantleyS Soltoff
Jun 1, 1991·Cancer Metastasis Reviews·U Rodeck, M Herlyn
Jul 5, 1991·Science·M HollsteinC C Harris
Nov 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·H C Pitot
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D E BrashJ Pontén
Nov 22, 1991·Science·E SolomonA D Goddard
Jan 25, 1991·Cell·J M Bishop
Jan 25, 1991·Cell·C J Marshall
Apr 1, 1991·Pediatric Clinics of North America·L J Helman, C J Thiele
Jun 6, 1991·Nature·A J LevineC A Finlay
Nov 1, 1990·Journal of the American Academy of Dermatology·Y D EliezriG J Nuovo
Jan 1, 1990·Pharmacology & Therapeutics·J A Boyd, J C Barrett
Sep 21, 1989·Nature·M J Berridge, R F Irvine
Apr 1, 1989·Current Opinion in Cell Biology·R H Michell
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A Wells, J M Bishop
Jan 1, 1986·Annual Review of Cell Biology·L Stryer, H R Bourne
Jan 16, 1987·Science·J M Bishop
Jan 1, 1985·Advances in Cancer Research·R Sager
Jan 1, 1985·Sovetskaia meditsina·E B PolevaiaT L Koposova
Nov 1, 1974·Journal of the National Cancer Institute·M L Kripke
Jan 1, 1974·CRC Critical Reviews in Toxicology·R K Boutwell
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Sep 1, 1984·Molecular and Cellular Biology·W Maltzman, L Czyzyk

❮ Previous
Next ❯

Citations

Feb 19, 2005·Current Oncology Reports·Stephen Y Lai, Randal S Weber
Apr 6, 2012·Annales de chirurgie plastique et esthétique·B Pinatel, A Mojallal
Jul 1, 2004·The British Journal of Oral & Maxillofacial Surgery·A W WilsonJ V Townend
Jul 14, 1998·International Journal of Oral and Maxillofacial Surgery·J G de Visscher, I van der Waal
Apr 4, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Richard B CannonJason P Hunt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.