Carcinogenic and genotoxic activity of extracts from contaminated sediments in western Lake Ontario

The Science of the Total Environment
C D MetcalfeB P Dunn


In order to investigate the putative association between chemical contamination in western Lake Ontario and high prevalences of fish tumors, sediments from Hamilton Harbour and Oakville Creek in Lake Ontario and reference sites in non-polluted areas of Ontario, Canada were collected and extracted for organic contaminants. Sediment extracts from Hamilton Harbour had the highest concentrations of polychlorinated biphenyls and organochlorine insecticides (ppb) and contained very high concentrations of polynuclear aromatic hydrocarbons (ppm); although the levels of these compounds varied widely with sampling location in the harbor. A sediment extract from Hamilton Harbour was mutagenic in the Ames bacterial assay, both with and without microsomal activation. High levels of aromatic DNA adducts were induced in cultured mouse C3H1OT1/2 cells after in vitro exposure to Hamilton Harbour sediment extract. In two separate carcinogenicity experiments involving a sac fry microinjection assay with rainbow trout (Oncorhynchus mykiss), Hamilton Harbour sediment extract induced hepatocellular carcinomas in fish. No hepatic neoplasms were observed in fish that had been treated with sediment extract from Oakville Creek, or with extract from a re...Continue Reading


Sep 29, 1978·Annals of the New York Academy of Sciences·R A Sonstegard
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
May 1, 1990·The Science of the Total Environment·M A HayesH W Ferguson
May 1, 1983·Mutation Research·D M Maron, B N Ames
Jan 1, 1980·Environmental Mutagenesis·J B Johnston, P K Hopke

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May 1, 1990·The Science of the Total Environment·M A HayesH W Ferguson
Jun 7, 2002·The Science of the Total Environment·Mark E Hahn
May 30, 2009·Ecotoxicology and Environmental Safety·Paula Suares RochaHenner Hollert
Apr 29, 2006·Environmental Toxicology·Michael A LewisCynthia A Chancy
Dec 2, 2004·Mutation Research·Guosheng Chen, Paul A White
Jan 1, 1996·Environmental and Molecular Mutagenesis·P A WhiteC Blaise
Sep 1, 1996·Toxicologic Pathology·T E Bunton
Jul 29, 2005·The International Journal of Social Psychiatry·Kam-Shing Yip
Apr 15, 2020·Environmental Science and Pollution Research International·Yenny RisjaniChristophe Minier

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