Carcinogenic HPV infection in the cervical squamo-columnar junction

The Journal of Pathology
Jelena MirkovicMichael Herfs

Abstract

Recent studies have suggested the involvement of a unique population of cells at the cervical squamo-columnar junction (SCJ) in the pathogenesis of early (squamous intraepithelial lesion or SIL) and advanced (squamous cell and adeno-carcinomas) cervical neoplasia. However, there is little evidence to date showing that SCJ cells harbour carcinogenic HPV or are instrumental in the initial phases of neoplasia. This study was designed to (1) determine if normal-appearing SCJ cells contained evidence of carcinogenic HPV infection and (2) trace their transition to early SIL. Sections of cervix from high-risk reproductive age women were selected and SCJ cells were analysed by using several techniques which increasingly implicated HPV infection: HPV DNA (genotyping and in situ hybridization)/RNA (PCR), immunostaining for HPV16 E2 (an early marker of HPV infection), p16(ink4), Ki67, and HPV L1 protein. In 22 cases with a history of SIL and no evidence of preneoplastic lesion in the excision specimen, HPV DNA was isolated from eight of ten with visible SCJ cells, six of which were HPV16/18 DNA-positive. In five of these latter cases, the SCJ cells were positive for p16(ink4) and/or HPV E2. Transcriptionally active HPV infection (E6/E7 mR...Continue Reading

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Citations

Dec 2, 2015·Infectious Agents and Cancer·Gabriela Elizabeth Campos-ViguriGloria Fernández-Tilapa
Dec 16, 2016·The Journal of Pathology·Michael HerfsPhilippe Delvenne
Apr 9, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sally RobertsJoanna L Parish
Jun 3, 2015·Nature Reviews. Clinical Oncology·Michael Herfs, Christopher P Crum
Sep 10, 2019·The American Journal of Surgical Pathology·Abha GoyalEdyta C Pirog
Oct 20, 2017·Beilstein Journal of Nanotechnology·Tatiana Novikova
Nov 28, 2019·The Journal of Biological Chemistry·Kuo LiuBin Zhou
Jan 22, 2020·The Journal of Pathology. Clinical Research·Eiichi SasakiYasushi Yatabe
Jun 20, 2020·AJR. American Journal of Roentgenology·Bahar MansooriDaniella F Pinho
Oct 1, 2016·Reproductive Sciences·Ahmed FadielFrederick Naftolin
Jun 24, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Olaf ReichCharles Redman
Jun 28, 2018·Digestive Diseases and Sciences·Sama I SayinMichael Quante
Mar 3, 2018·Nature Reviews. Cancer·Richard B S Roden, Peter L Stern
Nov 20, 2020·Veterinary Pathology·Shannon KirejczykSanjeev Gumber
Nov 19, 2020·Journal of Clinical Medicine·Justyna Pisarska, Katarzyna Baldy-Chudzik
Feb 20, 2021·Tumour Virus Research·Peter L Stern
May 1, 2017·Reproductive Sciences·Ahmed FadielFrederick Naftolin

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