PMID: 861Nov 25, 1975

Carcinogenic N-nitro-dimethylamine from the reaction of the analgesic amidopyrine and nitrite extracted from foodstuffs

Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology
J LaBar, J Sander

Abstract

The reaction of the analgesic amidopyrine (100 mg) with nitrite extracted from cured meats and from spinach in varying degrees of spoilage was studied. Unde physiological conditions the carcinogenic dimethylnitrosamine was formed at milligram levels at nitrite concentrations as low as 4 mg (in 175 ml extracted from 100 g boiled ham). The rate of decrease in concentration in the human stomach after ingestion of amidopyrine and of nitrite contained in boiled ham or in a broth from boiled ham was also measured.

References

Jan 1, 1974·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·S S MirvishS Arnold
Jun 15, 1967·Experientia·D Schmähl, H Osswald
Apr 12, 1972·Nature: New Biology·W Lijinsky, M Greenblatt
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J J KammJ J Burns
Sep 15, 1972·Nature·W LijinskyR Van de Bogart
Apr 1, 1973·Journal of the National Cancer Institute·M Greenblatt
Oct 10, 1970·Nature·R Montesano, P N MAGEE
Jul 1, 1969·Food and Cosmetics Toxicology·N P SenL Schwinghamer
Oct 15, 1965·Deutsche medizinische Wochenschrift·A Sinios, W Wodsak
Jul 1, 1962·The Journal of Pathology and Bacteriology·P N MAGEE, J M BARNES

Citations

Dec 1, 1978·Ecotoxicology and Environmental Safety·E J Olajos, F Coulston
Jun 12, 1978·Annals of the New York Academy of Sciences·M Göthert, N Klupp

Related Concepts

Eufibron
Digestion
Dimethylnitrosamine
Nutrients
Food Preservatives
Food Processing Industry
Gastric Juice
Hydrogen-Ion Concentration
Food, Drug and Cosmetic Act
Malignant Neoplasm of Liver

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