Nov 25, 1975

Carcinogenic N-nitro-dimethylamine from the reaction of the analgesic amidopyrine and nitrite extracted from foodstuffs

Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology
J LaBar, J Sander


The reaction of the analgesic amidopyrine (100 mg) with nitrite extracted from cured meats and from spinach in varying degrees of spoilage was studied. Unde physiological conditions the carcinogenic dimethylnitrosamine was formed at milligram levels at nitrite concentrations as low as 4 mg (in 175 ml extracted from 100 g boiled ham). The rate of decrease in concentration in the human stomach after ingestion of amidopyrine and of nitrite contained in boiled ham or in a broth from boiled ham was also measured.

  • References11
  • Citations3


  • References11
  • Citations3

Mentioned in this Paper

Spinach preparation
Gastric Juice
Spinacia oleracea
Nitrite Measurement
Analgesic brand of acetaminophen-phenyltoloxamine
Spinach allergenic extract

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