Carcinogenicity and chronic toxicity of hydrazine monohydrate in rats and mice by two-year drinking water treatment

Regulatory Toxicology and Pharmacology : RTP
Michiharu MatsumotoS Fukushima

Abstract

The carcinogenicity and chronic toxicity of hydrazine monohydrate was examined by administrating hydrazine monohydrate in drinking water to groups of 50 F344/DuCrj rats and 50 Crj:BDF1 mice of both sexes for two years. The drinking water concentration of hydrazine monohydrate was 0, 20, 40 or 80 ppm (wt/wt) for male and female rats and male mice; and 0, 40, 80 or 160 ppm for female mice. Survival rates of each group of males and females rats and mice were similar to the respective controls, except female rats administered 80 ppm. Two-year administration of hydrazine monohydrate produced an increase in the incidences of hepatocellular adenomas and carcinomas in rats of both sexes along with hepatic foci. In mice, the incidences of hepatocellular adenomas and carcinomas were increased in females, and significantly increased incidences of hepatocellular adenomas in females administered 160 ppm were observed. Thus, hydrazine monohydrate is carcinogenic in two species, rats and mice. Additionally, non-neoplastic renal lesions in rats and mice and non-neoplastic nasal lesions in mice were observed.

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Citations

Jan 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Theano D KarakostaParaskevas D Tzanavaras
Dec 28, 2019·Materials·Andrea Pietro ReverberiBruno Fabiano
Sep 21, 2020·Environmental and Molecular Mutagenesis·John NicoletteMeredith Crosby
Oct 17, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shun WangWencai Huang
Mar 14, 2020·ACS Applied Materials & Interfaces·Vaishakh KedambaimooleRajanna Konandur

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