PMID: 11317703Apr 25, 2001Paper

Carcinogenicity assays of wood dust and wood additives in rats exposed by long-term inhalation

International Archives of Occupational and Environmental Health
R G KleinJ Wolf

Abstract

This study evaluates whether wood dust and/or wood preservatives develop a carcinogenic potential against the tissues of the airways of rats. The formation of tumors of the respiratory tract after exposure to wood dust was studied in six groups of approximately 60 female Fischer 344 rats exposed by long-term inhalation to mean concentrations of (1) 18 mg/m3 of untreated oak wood dust, (2) wood preservatives containing ca. 1 microgram/m3 lindane and 0.2 microgram/m3 of pentachlorophenol (PCP) in the exposure air, or lindane and 18 micrograms/m3 of PCP (group lindane/PCP vapors, and group oak wood treated with lindane/PCP), (3) 21 or 39 micrograms/m3 of sodium dichromate (calculated as CrO3, group chromate aerosol and group oak wood with chromate), and 72 micrograms/m3 of N-nitrosodimethylamine vapors as positive control. The negative control group consisted of 115 animals (sham-exposed). Tumors of the nasal cavity developed in two rats exposed to chromate aerosol or in combination with wood dust (2/102, 2%). Malignant tumors of the lower respiratory tract were induced only in exposed groups of rats (three adenocarcinomas of the lung and four bronchiolar lung carcinomas, 7/254, 2.8%). More respiratory tract tumors were observed i...Continue Reading

Citations

Jan 26, 2005·Journal of Applied Toxicology : JAT·Sidney A Katz, Harry Salem
Dec 19, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A J García-FernándezD Ordóñez
Mar 29, 2011·Chemosphere·Avima M Ruder, James H Yiin
Mar 1, 2009·Environmental Toxicology and Pharmacology·Rita Cerejeira MatosJúlio Pedrosa de Jesus
Jun 6, 2014·Environmental Toxicology·Mark J WilsonCharles A Miller
Jul 28, 2016·Otolaryngologic Clinics of North America·Anne Morgan SelleckAdam M Zanation
Jun 3, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Juha MäättäHarri Alenius
Nov 30, 2016·Journal of Nanobiotechnology·Chiara CivardiFrancis W M R Schwarze

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