PMID: 6987506Jan 1, 1980Paper

Carcinogenicity, teratogenicity and mutagenicity of arsenic

Mutation Research
A Léonard, R R Lauwerys

Abstract

Arsenic may be released into the environmental through industrial processes and through the generation of power from coal. It is also widely used in agriculture and was formerly used extensively in medicine. For the general population, exposure to arsenic occurs mainly through the ingestion of foodstuffs containing inorganic and organic arsenicals. Trivalent arsenicals are regarded as being primarily sulfhydryl reagents with the result they inhibit a number of thiol-dependent enzymic systems in various tissues. Arsenite also has an effect on DNA synthesis and DNA repair. Owing to its lower affinity for hydroxy and thiol groups, pentavalent arsenate inhibits fewer enzymic systems. Although there is no reliable evidence that arsenic produces tumors in experimental animals, epidemiological studies show that the incidence of epidermoid carcinomas of the skin and lungs, and of pre-cancerous dermal keratoses, is significantly increased in human subjects who have been chronically exposed to arsenic compounds by oral or respiratory routes. Arsenic appears to be one of the only teratogenic members of the Group V metals. Most of the studies performed on the mutagenic activity of arsenic have provided positive results. They involve experi...Continue Reading

References

Aug 1, 1977·Environmental Health Perspectives·T G RossmanW Troll
Mar 1, 1978·Archives of Dermatology·F ReymannA Nielsen
Feb 1, 1978·British Journal of Industrial Medicine·O AxelsonS O Rehnlund
Jun 1, 1975·Mutation Research·H Nishioka
Jan 1, 1976·Mutation Research·Y ShirasuT Kada
Aug 1, 1977·Environmental Health Perspectives·S S PintoM O Varner
Aug 1, 1977·Environmental Health Perspectives·E A Crecelius
Aug 1, 1977·Environmental Health Perspectives·T Dutkiewicz
Oct 1, 1977·The Journal of Pediatrics·R G Peterson, B H Rumack
Jan 1, 1976·Annals of the New York Academy of Sciences·H P Blejer, W Wagner
Dec 1, 1975·Environmental Health Perspectives·J E Sabadell, R C Axtmann
Dec 1, 1975·Environmental Health Perspectives·S E LindbergW Fulkerson
Apr 1, 1972·Bulletin of Environmental Contamination and Toxicology·R D Hood
Sep 1, 1974·Toxicology and Applied Pharmacology·C D Klaassen
Apr 15, 1974·International Journal of Cancer. Journal International Du Cancer·M KuratsuneY Tokumitsu
Nov 1, 1974·Archives of Environmental Health·M G OttH L Gordon
Jun 1, 1972·Chemical Reviews·D R Williams
May 1, 1972·Journal of Agricultural and Food Chemistry·K J AndersonM T Takahashi
Nov 3, 1972·Nature·D L Johnson
Dec 1, 1973·Human Pathology·S Yeh
Aug 1, 1973·The Science of the Total Environment·M D LuhD E Henley
Feb 1, 1974·Archives of Environmental Health·S L Wagner, P Weswig
Jan 1, 1969·Archives of Environmental Health·J E Milner
Mar 1, 1969·Archives of Biochemistry and Biophysics·G L Cottam, P A Srere
Aug 1, 1970·Pediatric Clinics of North America·J J Chisolm
Feb 1, 1971·Food and Cosmetics Toxicology·F W Sunderman
Jan 1, 1972·Archives of Environmental Health·R D Hood, S L Bishop
Nov 1, 1972·Mutation Research·G R Paton, A C Allison
Oct 1, 1972·Teratology·R D Hood, C T Pike
Nov 1, 1969·The Journal of Allergy·H S Novey, S H Martel
Sep 1, 1969·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·G W Walker, A M Bradley
Jan 9, 1970·Deutsche medizinische Wochenschrift·J PetresU Wolf
May 1, 1971·Archives of Environmental Health·V H FermB M Smith
Oct 1, 1968·Journal of Reproduction and Fertility·V H Ferm, S J Carpenter
Mar 1, 1969·American Journal of Diseases of Children·G LugoP Palmisano
Mar 1, 1969·Toxicology and Applied Pharmacology·O A Levander, L C Argrett
Jun 1, 1969·Archives of Environmental Health·R E Holmberg, V H Ferm
Sep 1, 1966·Cancer·R H Holland, A R Acevedo
Sep 1, 1966·Brain : a Journal of Neurology·R B Jenkins
Jul 1, 1966·Toxicology and Applied Pharmacology·O A Levander, C A Baumann
Jan 1, 1958·Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin·F ROTH
Nov 1, 1962·Archives of Environmental Health·W C HUEPER, W W PAYNE
Jul 27, 1963·British Medical Journal·A O ROBSON, A M JELLIFFE

❮ Previous
Next ❯

Citations

Sep 19, 2002·Molecular Reproduction and Development·C E KriningerP J Hansen
Jan 1, 1991·Teratogenesis, Carcinogenesis, and Mutagenesis·K HondaM Yukioka
Oct 1, 1986·Archives of Toxicology·W U MüllerC Fischer-Lahdo
Jan 1, 1982·Archives of Toxicology·G B GerberB Eykens
Jan 1, 1984·Molecular & General Genetics : MGG·R Fahrig
Feb 1, 1989·Bulletin of Environmental Contamination and Toxicology·S H Goldstein, H Babich
Dec 1, 1991·Environmental Geochemistry and Health·M Goldman, J C Dacre
May 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·T C LeeH Huang
Feb 16, 2006·Journal of Biomedical Science·Wen-Jen LuJin-Ding Huang
Dec 16, 1992·Mutation Research·A N JhaA T Natarajan
Jan 1, 1988·Mutation Research·M D Shelby
Jul 1, 1988·Mutation Research·S Gómez-ArroyoR Villalobos-Pietrini
Dec 1, 1994·FEMS Microbiology Reviews·C CervantesS Silver
Feb 1, 1989·Toxicology Letters·H BabichE Borenfreund
Mar 1, 1990·Toxicology Letters·K Y JanT C Lee
Mar 1, 1995·Reproductive Toxicology·J L Domingo
Aug 4, 2004·Free Radical Biology & Medicine·Tom K Hei, Metka Filipic
May 15, 2004·Research in Microbiology·Laura GualcoEugenio A Debbia
Mar 5, 2004·Toxicology and Applied Pharmacology·Teruaki SakuraiKitao Fujiwara
Feb 4, 1998·Chemico-biological Interactions·T Gebel
Oct 31, 2008·Talanta·Badal Kumar Mandal, Kazuo T Suzuki
Apr 30, 1999·Toxicology Letters·D B MenzelR N Roth
Nov 5, 2013·Environmental Science & Technology·James U Van DykeWilliam A Hopkins
Jun 30, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M S GolubN Baumrind
Mar 13, 2008·Pharmacogenetics and Genomics·Alba HernándezRicardo Marcos
Nov 12, 2002·Environmental Health Perspectives·Jose A CentenoElena R Ladich
Sep 1, 1994·Environmental Health Perspectives·T C Lee, I C Ho

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