Abstract
Primary carcinoid tumours of the middle ear are extremely rare, only nine cases having been reported. However, their true incidence is probably greater, since they are very difficult or impossible to distinguish from adenomas and adenocarcinomas with conventional histological stains. We describe the clinical, histological, immunohistochemical and ultrastructural findings in a carcinoid tumour of the middle ear in a 50-year-old woman. Immunohistochemical studies on non-neoplastic middle ear mucosa undertaken to investigate the histogenesis of such tumours are also reported. Histologically, the tumour consisted of both solid areas and areas of tubular structures containing intraluminal mucus. All the tumour cells reacted with the anti-keratin antibody KL 1; some were argyrophil and reacted with antibodies against neuron-specific enolase, chromogranin A, Leu-7, serotonin, pancreatic polypeptide, glucagon and lysozyme. Electron microscopy revealed dense core granules in the tumour cells. Endocrine cells could not be detected in non-neoplastic middle ear mucosa. Pancreatic-polypeptide-like immunoreactivity was demonstrated immunohistochemically in all three other published cases of carcinoid tumour of the middle ear investigated for...Continue Reading
References
Jun 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I Nenci
Aug 12, 1977·Science·D A Price, M J Greenberg
Jan 1, 1986·Histopathology·S F Bonar, E C Sweeney
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·H K Müller-Hermelink, E Kaiserling
Nov 1, 1988·Acta Pathologica Japonica·M SakuraiY Kobayashi
Jan 1, 1987·Histochemistry·J H RomboutJ J Taverne-Thiele
Dec 15, 1987·Cancer·S MichelsM R Wick
May 1, 1987·The Journal of Laryngology and Otology·M A LatifP A Shaw
Mar 25, 1985·Brain Research·A InuiS Baba
Dec 1, 1971·The Annals of Otology, Rhinology, and Laryngology·D J Lim, H Birck
Dec 1, 1970·The Annals of Otology, Rhinology, and Laryngology·E Hentzer
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Dec 1, 1981·Cancer·J AlumetsS Tibblin
Jun 1, 1982·The American Journal of Surgical Pathology·F ClaytonG Hanssen
May 15, 1983·Cancer·K YangK J Lewin
Jan 1, 1983·Cell and Tissue Research·J B FurnessR E Chance
Oct 1, 1984·The Journal of Laryngology and Otology·R A TangeW M Mooi
Oct 1, 1984·The American Journal of Surgical Pathology·T KodamaJ Shimase
May 1, 1983·The Journal of Laryngology and Otology·I FriedmannP P Ward
Dec 11, 1981·Science·E WeberJ D Barchas
Aug 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·S InoueS Kannae
Dec 23, 2006·Seminars in Thoracic and Cardiovascular Surgery·Samuel P Hammar
Oct 1, 1987·Cell and Tissue Research·C M Myers, P D Evans
Citations
Jan 16, 1999·Head & Neck·E E MooneyR L Scher
Sep 6, 2001·Diagnostic Cytopathology·G Menezes, P Wakely
Apr 29, 1998·Pathology Oncology Research : POR·H BläkerH F Otto
Sep 1, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Richard SalzmanJiří Kučera
Aug 1, 1991·Journal of Clinical Pathology·R J HaleJ S Whittaker
Mar 6, 1999·Journal of Neurosurgery·W PaulusR Fahlbusch
Jul 20, 2016·Case Reports in Otolaryngology·Zubair HasanMelville da Cruz
Aug 1, 1995·The Annals of Otology, Rhinology, and Laryngology·A PollakU Fisch
Mar 5, 2020·Indian Journal of Cancer·Shakti Kumar YadavSonam Kumar Pruthi
Aug 1, 1992·Acta Pathologica Japonica·S HosodaT Konishi
Aug 6, 2021·Oral Oncology·M S D EngelE F Hensen
Jun 1, 2006·Annales de pathologie·Valérie Hervieu, Jean-Yves Scoazec