Carcinoma Arising from Brunner's Gland in the Duodenum after 17 Years of Observation - A Case Report and Literature Review

Case Reports in Gastroenterology
Masaru KoizumiYoshikazu Yasuda

Abstract

A 60-year-old man presented with melena and hematemesis in 1984. Esophagogastroduodenoscopy (EGD) detected a small protruding lesion in the duodenal bulb, which was diagnosed as Brunner's adenoma. No significant change was detected in subsequent annual EGD and biopsies for 10 years, after which the patient was not observed for 7 years. The patient presented with melena again in 2001. The lesion had changed shape to become a 10 mm sessile tumor with a central depression, and following a biopsy was diagnosed as an adenocarcinoma. The patient underwent partial resection of the duodenum. Histopathological assessment showed acidophilic cells with swollen nuclei, and clear cells forming a tubular or papillary tubule in the mucosal lamina propria and submucosal layer. The tumor cells stained positive for lysozyme, indicating that they arose from Brunner's gland. The patient showed no sign of recurrence and was disease-free for more than 34 months after surgery. The patient died of pneumonia. This is an extremely rare case of primary duodenal carcinoma arising from Brunner's gland in a patient observed for 17 years.

References

Apr 1, 1977·Cancer·I A SpiraW I Wolff
Mar 1, 1986·Journal of the Royal Society of Medicine·K ShorrockR D Leach
Jun 1, 1974·Archives of Surgery·W M MossD R Miller
Mar 1, 1994·Gastrointestinal Endoscopy·K KawamotoT Katsuyama
Feb 1, 1993·Gastroenterologia Japonica·M ItsunoH Watanabe
Feb 19, 2000·Journal of Gastroenterology·E FujimakiY Takeda
May 8, 2002·Journal of Gastroenterology·Kimishige AkinoKohzoh Imai

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Citations

Dec 4, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hyuk Soon ChoiHoon Jai Chun
Feb 28, 2015·International Journal of Surgery Case Reports·Ichiro TamakiTaisuke Morimoto
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·K Martin HoffmannRobert T Jensen
Dec 28, 2017·Journal of Pathology and Translational Medicine·Ji Hye MoonWoo Ho Kim
Sep 15, 2015·Journal of the Belgian Society of Radiology·E OzturkB Hekimoglu
Jan 19, 2018·Journal of Epilepsy Research·Emilio Perucca
Apr 2, 2018·Clinical Journal of Gastroenterology·Yasumasa MatsuoFumio Itoh
May 18, 2017·Case Reports in Gastrointestinal Medicine·Masaya IwamuroHiroyuki Okada

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Methods Mentioned

BETA
biopsies
biopsy

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