Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression

British Journal of Cancer
S StriethN E Fusenig

Abstract

Differential diagnosis between keratoacanthomas and well differentiated squamous cell carcinomas based on clinical and histomorphological data is problematic. Recent findings of cellular atypia in a large proportion of keratoacanthomas indicated that these potentially 'self-healing' cutaneous neoplasms had the potential for malignant progression. Another malignancy-associated criterion is enhanced angiogenesis with increased microvessel density. To provide further diagnostic markers for keratoacanthomas we examined microvessel density on paraffin sections of 13 keratoacanthomas in comparison with 10 normal skin biopsies and 16 late-stage skin squamous cell carcinomas by counting and by computer-assisted image analysis of CD31-immunostained vessels. A significant increase of microvessel density in 'hot spots' was observed in keratoacanthomas as compared to normal skin. Furthermore, when keratoacanthomas were subdivided into tumours with and without malignancy-associated atypic areas, only those with atypia (n=6) were significantly better vascularised than normal skin and had a mean microvessel density in the range of late-stage squamous cell carcinomas. Both keratoacanthoma subtypes revealed comparable levels of inflammatory cel...Continue Reading

References

Dec 1, 1979·Journal of Surgical Oncology·R A Schwartz
Jan 1, 1979·The British Journal of Dermatology·A Rook, I Whimster
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Jun 1, 1991·Environmental Health Perspectives·M CorominasA Pellicer
Nov 1, 1990·American Journal of Clinical Pathology·H BreuningerG Rassner
Feb 1, 1990·American Journal of Clinical Pathology·M B RandallR W Prichard
Feb 1, 1986·Journal of the American Academy of Dermatology·B R SmollerS Banks-Schlegel
Dec 1, 1972·Archives of Dermatology·R J Reed
Oct 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M Hsu, E Soban
Oct 1, 1993·Journal of Cutaneous Pathology·P Phillips, K F Helm
Apr 1, 1993·The Histochemical Journal·A F MoormanW H Lamers
Aug 1, 1993·The American Journal of Dermatopathology·E HodakA B Ackerman
Jan 1, 1994·Journal of the American Academy of Dermatology·R A Schwartz
Feb 1, 1994·Archives of Dermatology·R L KerschmannPhilip E LeBoit
Nov 14, 1997·Nature Medicine·M SkobeN E Fusenig
May 26, 1998·Annals of Plastic Surgery·C H MansteinJ E Besden
Jun 12, 1999·Journal of Cutaneous Medicine and Surgery·E M BillingsleyK F Helm
Dec 11, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·B CribierE Grosshans
Feb 22, 2000·British Journal of Cancer·S StriethN E Fusenig
Aug 19, 2000·The American Journal of Dermatopathology·E Sánchez YusE de Eusebio
Jun 1, 1997·The Australasian Journal of Dermatology·R S Barnetson, G M Halliday
Aug 3, 2001·Cancer Control : Journal of the Moffitt Cancer Center·M H RinkerL F Glass
Apr 30, 2002·The American Journal of Dermatopathology·Philip E LeBoit

Citations

Aug 5, 2017·Journal of Cellular Biochemistry·Razieh KhanmohammadiHamed Mirzaei
Feb 6, 2004·Plastic and Reconstructive Surgery·Stefan O P Hofer, Ian T Jackson
May 16, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tiina T KuivanenUlpu K Saarialho-Kere
Apr 13, 2019·Head and Neck Pathology·Efthimios SivridisAlexandra Giatromanolaki

Methods Mentioned

BETA
flow cytometry
biopsies
transgenic

Related Concepts

Biopsy
Squamous Cell Carcinoma
Neoplastic Cell Transformation
Differential Diagnosis
Optical Image Reconstruction
Immunocytochemistry
Keratoacanthoma
Microcirculation
Pathologic Neovascularization
Dermatologic Disorders

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