PMID: 25743829Mar 7, 2015Paper

Carcinoma microsatellite instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for stage II rectal cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Liu YangXin Guan

Abstract

Rectal cancers with high microsatellite-instable have clinical and pathological features that differentiate them from microsatellite-stable or low- frequency carcinomas, which was studied rarely in stage II rectal cancer, promoting the present investigation of the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II rectal cancer. Data of 460 patients who underwent primary anterior resection with a double stapling technique for rectal carcinoma at a single institution from 2008 to 2012 were retrospectively collected. All patients experienced a total mesorectal excision (TME) operation. Survival analysis were analyzed using the Cox regression method. Five-year rate of disease-free survival (DFS) was noted in 390 (84.8%) of 460 patients with stage II rectal cancer. Of 460 tissue specimens, 97 (21.1%) exhibited high-frequency microsatellite instability. Median age of the patients was 65 (50-71) and 185 (40.2%) were male. After univariate and multivariate analysis, microsatellite instability (p= 0.001), female sex (p< 0.05) and fluorouracil-based adjuvant chemotherapy (p< 0.001), the 3 factors were attributed to a favorable survival status independently...Continue Reading

References

May 7, 1993·Science·S N ThibodeauD Schaid
Apr 10, 1997·Nature·C LengauerB Vogelstein
Aug 5, 1999·Journal of the National Cancer Institute·K C HallingS N Thibodeau
Jan 13, 2000·The New England Journal of Medicine·R GryfeS Gallinger
Dec 16, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Olayiwola O OduwolePirkko T Vihko
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PopatR S Houlston
May 6, 2005·Diseases of the Colon and Rectum·Joe J TjandraUNKNOWN American Society of Colon and Rectal Surgeons
Aug 4, 2005·Nature Clinical Practice. Oncology·Rachel Midgley, David J Kerr
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giovanni LanzaLuigi Cavazzini
Sep 9, 2008·Gastroenterology·William M Grady, John M Carethers
Mar 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Monica M BertagnolliMark Redston
May 12, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gaëtan Des GuetzBernard Uzzan
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thierry AndréAimery de Gramont
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Jul 26, 2012·British Journal of Cancer·A RudolphJ Chang-Claude
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Liu YangJian-Nong Zhou
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Liu YangXin Guan
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jian-Ping GongDong-Feng Wang
Dec 17, 2014·Epigenetics : Official Journal of the DNA Methylation Society·V L J WhitehallB A Leggett

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Citations

Jun 22, 2018·Oncology Letters·Ha Thi Nguyen, Hong-Quan Duong
Apr 30, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Xue-Yan Wu, Xin-En Huang
May 28, 2017·Journal of Gastrointestinal Cancer·Winson Jianhong TanMin Hoe Chew

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