PMID: 6406405May 1, 1983Paper

Carcinoma of the hypopharynx results of primary radical radiation therapy

International Journal of Radiation Oncology, Biology, Physics
T J KeaneW D Rider

Abstract

The results of radiation therapy as applied to patients with squamous cell carcinoma of the hypopharynx seen during the period 1972-1976 at the Princess Margaret Hospital are presented. Approximately 2/3 of the patient population presented with disease involving the regional lymph nodes or with systemic metastases. Ninety percent (127/141) of all patients registered were treated primarily with radiation therapy with surgery reserved for the management of residual or recurrent disease only. Seventy-seven percent (98/127) of those who received radiation therapy were treated with radical intent. The uncorrected actuarial 5 year survival rate for those patients treated radically was 19%. Five year actuarial survival rates by the UICC TNM (1974) staging system, showed that nodal disease was the most significant determinant of survival. Five year survival rates were as follows: N0 36%; N1 20%; N2N30%. When considered within each nodal category the survival of the combined T1T2 group was not significantly different from the T3 category. Forty-five percent of those patients who failed with local or regional disease had an attempt at salvage surgery. Of these, 6/24 ultimately achieved local and regional control. Comparisons with other s...Continue Reading

References

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Citations

Sep 1, 1988·International Journal of Radiation Oncology, Biology, Physics·R ScottE Pakuris
Oct 19, 1999·International Journal of Radiation Oncology, Biology, Physics·R MacKenzieE Franssen
May 14, 2010·Japanese Journal of Clinical Oncology·Masahiro MorimotoYasuhiko Tomita
Jun 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J Bernier, J P Bataini
Sep 24, 1999·Hematology/oncology Clinics of North America·M L Gillison, A A Forastiere
Jan 1, 1988·Acta Oncologica·H R WithersB Maciejewski
Jun 1, 1995·Clinical Otolaryngology and Allied Sciences·M M EliasA J Balm
Jun 23, 2007·Japanese Journal of Clinical Oncology·Mitsuhiko KawashimaTakashi Ogino
Apr 6, 2004·Surgical Oncology Clinics of North America·Christine G Gourin, David J Terris

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