PMID: 9180911Aug 1, 1997Paper

Carcinoma of the thyroid in children: a 25-year experience

Medical and Pediatric Oncology
A J Sykes, H R Gattamaneni

Abstract

Over the past 25 years, 23 children with carcinoma of the thyroid have been treated at the Christie Hospital, Manchester. Twenty-one cases were well-differentiated carcinoma, and two were medullary carcinoma. They were all treated by resection, 14 with total thyroidectomy and 9 with lobectomy or subtotal thyroidectomy. Sixteen children also had surgery for nodal disease. Two children presented with lung metastases. Sixteen children received post-operative radiotherapy (4 external beam, 12 131I). Median follow-up of 67 months (range 7-233), was the same for the 21 well-differentiated carcinomas and the whole group including the two medullary carcinomas. All 21 children with well-differentiated carcinomas are alive with no evidence of progressive disease. Two relapsed after total thyroidectomy, but both were salvaged, one with external beam radiotherapy, one with 131I. One child with medullary carcinoma died with progressive disease after 43 months, the other is alive, but with slowly progressive disease 145 months after diagnosis. Ten of 14 children experienced post-operative hypocalcaemia following total thyroidectomy, in 7 cases it persisted long-term. 131I and external beam radiotherapy were both well tolerated. The long-term...Continue Reading

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Citations

Sep 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Wellington Hung, Nicholas J Sarlis
Sep 24, 2010·Thyroid : Official Journal of the American Thyroid Association·Melissa PawelczakBina Shah
May 26, 2009·Medicina clínica·Montserrat Negre BusóJoan Castell Conesa
Aug 21, 2007·Seminars in Nuclear Medicine·Marguerite T Parisi, David Mankoff
Apr 19, 2013·Scottish Medical Journal·C M Douglas, F B Macgregor
Oct 3, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Aron PopovtzerKarol Segal
Mar 13, 2018·Pediatric Blood & Cancer·Maura MassiminoArchie Bleyer
Jul 28, 2005·Pediatric Blood & Cancer·Paola ColliniUNKNOWN Thyroid Cancer Study Group of the Istituto Nazionale Tumori of Milan, Italy
Feb 26, 2000·Pediatric Hematology and Oncology·M W Ben ArushA Kuten
Dec 11, 2003·The Journal of Urology·Eli SomekhFrancis Serour
Jun 1, 2005·Pediatric Blood & Cancer·Maura MassiminoUNKNOWN Thyroid Cancer Study Group of the Istituto Nazionale Tumori of Milan, Italy
Sep 3, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Montserrat Negre BusóJoan Castell Conesa

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