PMID: 6169661Mar 15, 1981Paper

Carcinomas induced by cell lines cultivated from normal mouse placentas

International Journal of Cancer. Journal International Du Cancer
T LogY C Hsu

Abstract

Cell lines have been established from placentas of various strains of mice by in vitro cultivation. The established lines appear to be trophoblast cells as judged from their production of gonadotropin-like substance and their production of gonadotropin-like substance and steroid hormones. The cell lines lack detectable H-2 antigen, Fc receptor sites, Thy 1 and antigen and surface immunoglobulin determinants. In addition, the cells are resistant to murine type-C RNA tumor virus infection. The resistance is due to a block of viral replication after the stages of viral adsorption and penetration. The cell lines induced carcinomas after injection into adult mice of original host strains. Usually at least 2 x 10(6) cells are required to induce tumors by i.p. or s.c. injection. Transplantation of the tumor cells to various strains of mice revealed that some strains accepted and some strains rejected the transplant. Genetic crossings between susceptible and resistant mouse strains indicate that susceptibility to transplantation of tumor is determined by a single pair of dominant autosomal genes.

References

Sep 1, 1979·Journal of Reproduction and Fertility·L Wide, M Wide
Sep 1, 1977·Nature·M H Sellens
Apr 1, 1967·Lancet·G A Currie, K D Bagshawe
Mar 1, 1972·The Journal of Experimental Medicine·A BastenJ Pye
Aug 1, 1961·The Journal of Obstetrics and Gynaecology of the British Commonwealth·H D ATTWOOD, W W PARK
Nov 1, 1959·American Journal of Obstetrics and Gynecology·G W DOUGLASR MORRIS
Apr 2, 1964·The New England Journal of Medicine·R E BILLINGHAM
Nov 7, 1964·Nature·D R KIRBYD J GOLDSTEIN
Jan 1, 1965·The American Journal of Anatomy·T W TAO, A T HERTIG

❮ Previous
Next ❯

Citations

Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K TanakaE Appella
Apr 15, 1990·International Journal of Cancer. Journal International Du Cancer·A VerstuyfM Vandeputte
Mar 1, 1988·Placenta·J S HuntM J Soares
Nov 15, 1989·International Journal of Cancer. Journal International Du Cancer·A VerstuyfM Vandeputte
Mar 15, 1982·International Journal of Cancer. Journal International Du Cancer·K Tanaka, K S Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.