Carcinosarcoma of the ovary: MR and clinical findings compared with high-grade serous carcinoma.

Japanese Journal of Radiology
Tsukasa SaidaManabu Minami

Abstract

To clarify imaging and clinical characteristics of ovarian carcinosarcoma (CS) compared with high-grade serous carcinoma (HGSC). We retrospectively reviewed MR imagings of 12 patients with CS and 30 patients with HGSC and evaluated tumor size, shape, appearance, nature of cystic and solid components, hemorrhage, and necrosis. Age, premenopausal or postmenopausal, histologic subtype, presence of endometriosis, tumor markers, and stage were also evaluated. These parameters were compared using the Mann-Whitney U test and the chi-square test/Fisher's exact test. The mean size of CSs was 13.6 cm, and significantly larger than that of HGSCs (mean 9.0 cm, p = 0.022). The stained-glass appearance (67% vs. 23%, p = 0.013), hemorrhage (100% vs. 50%, p = 0.003), necrosis (75.0% vs. 13%, p = 0.000), and endometriosis (33% vs. 7%, p = 0.012) were significantly more common in CSs. The postmenopausal ratio of CSs was 100% and significantly higher than that of HGSCs (70.0%, p = 0.041). Among the tumor makers, only CA-125 was significantly lower in CSs than in HGSCs (mean 715.1 U/ml vs. 1677.1 U/ml, p = 0.009). The stage distribution was similar and was not significantly different. CSs formed larger masses, and the stained-glass appearance, hem...Continue Reading

References

Jul 12, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C GourleyH Gabra
Jun 10, 2004·European Journal of Radiology·C Zuhal ErdemErdal Kaya
Jul 31, 2008·Journal of Magnetic Resonance Imaging : JMRI·Yumiko O TanakaManabu Minami
Jun 26, 2010·European Journal of Radiology·Yumiko O TanakaManabu Minami
Dec 14, 2011·Gynecologic Oncology·Marcela G del CarmenJohn O Schorge
Feb 14, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Yumiko Oishi TanakaManabu Minami
May 12, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ileana W CarnevaliMaria Grazia Tibiletti
Nov 3, 2016·Journal of Obstetrics and Gynaecology of India·Sangeeta PankajVivek Kumar Roy
Dec 16, 2017·Pathology·Xavier Matias-Guiu, Colin J R Stewart
May 29, 2018·CA: a Cancer Journal for Clinicians·Lindsey A TorreRebecca L Siegel
Jul 18, 2018·Gynecologic Oncology Reports·Khalid AminMahmoud A Khalifa
Dec 13, 2018·Nuclear Medicine and Molecular Imaging·Soyoung KimWon Jun Kang
Feb 18, 2019·Critical Reviews in Oncology/hematology·Stergios BoussiosKonstantina Tatsi
Jul 10, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jamie MarkoDarcy J Wolfman

❮ Previous
Next ❯

Citations

Oct 2, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sanjay RaoSree Harsha Tirumani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.