Carcinosarcoma of the upper urinary tract with an aggressive angiosarcoma component

Cancer Biology & Therapy
José Luis Cuadra UrteagaMiquel Taron

Abstract

Carcinosarcomas (CS) are biphasic tumors with malignant epithelial and mesenchymal elements. The sarcomatoid elements of CS can include chondrosarcoma, malignant fibrous histiocytoma, osteosarcoma, leiomyosarcoma, fibrosarcoma, or liposarcoma. CS of the upper urinary tract are extremely rare but are associated with a poor prognosis. We report a case of a 44-year-old man with a localized right renal pelvis mass treated with a right nephroureterectomy. The pathological examination showed a high-grade urothelial carcinoma of the renal pelvis, stage III (pT3aNxM0). A few days later, he developed lower back pain, hematuria, cough with hemoptoic sputum and progressive dyspnea. Radiological explorations showed multiple bilateral lung nodules and a retroperitoneal mass. A CT-guided biopsy of the retroperitoneal mass revealed a high-grade angiosarcoma. A review of the nephrectomy specimen showed a microscopic focus of angiosarcoma in the urothelial carcinoma. Therefore, the initial diagnosis was changed to CS of the renal pelvis with an angiosarcoma component. The patient developed progressive respiratory failure and died 8 weeks after surgery. An autopsy revealed a large retroperitoneal mass with metastatic nodules to the abdominal wal...Continue Reading

References

Jul 1, 1977·Postgraduate Medical Journal·M S RaoD H McGregor
Jan 1, 1990·Histopathology·C A BloxhamM C Robinson
Jan 1, 1984·European Urology·S YanoS Fukuda
Apr 29, 1998·The Journal of Urology·A Lopez-BeltranD G Bostwick
Jan 17, 2004·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Erkan YilmazSoner Guney
Nov 23, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Angela DarkoDebra Heller
Jan 4, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Senji HoshiShunichi Saso
Nov 11, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew B ArmstrongLiang Cheng
Nov 19, 2008·Renal Failure·Kuan-Chi ChiuChen-Yin Chen

❮ Previous
Next ❯

Citations

Feb 16, 2019·International Journal of Surgical Pathology·Kosuke TakemuraFumitaka Koga
Sep 12, 2018·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Guglielmo ManticaCarlo Terrone

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
biopsy

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.

Related Papers

Hinyokika kiyo. Acta urologica Japonica
Hirofumi IshimuraHidekachi Kurotaki
Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica
Pietro PepeFrancesco Aragona
International Journal of Clinical and Experimental Pathology
Makiko OgawaMasashi Fukayama
© 2022 Meta ULC. All rights reserved